{"doi":"10.1371/journal.pone.0277655","title":"Predictors of large cell transformation in patients with Sezary Syndrome—A retrospective analysis","abstract":"BACKGROUND: Large cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its development. OBJECTIVES: Here, we seek to characterize the clinicopathologic risk factors that predispose patients with SS to develop LCT. METHODS: We retrospectively evaluated all SS patient records available in the Michigan Medicine Cancer Registry from 2010-2021. Clinical and pathologic variables were compared between groups. The Kaplan-Meier method and log-rank test were used to assess overall survival. RESULTS: Of 28 SS patients identified, eight patients experienced LCT, and 20 did not (NLCT). Peak lactate dehydrogenase (LDH) before LCT (p = 0.0012), maximum total body surface area (TBSA) involvement before LCT (p = 0.0114), absolute CD8+ cell count measured on flow cytometry at diagnosis of SS (p = 0.0455) and at the most recent blood draw (p = 0.00736), and ulceration on biopsy (p = 0.0034) were significant clinicopathologic variables identified between the SS patients that developed LCT versus those that did not. CONCLUSIONS: Maximum TBSA involvement, peak LDH, presence of ulceration, and decreased levels of CD8+ cells in the peripheral blood may predict the development of LCT in patients with SS.","journal":"PLoS ONE","year":2022,"id":294064,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8247,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":427005,"name":"Redina Bardhi","orcid":null,"position":1,"is_corresponding":false},{"id":581764,"name":"John S. Runge","orcid":"0000-0001-6489-8575","position":2,"is_corresponding":false},{"id":581765,"name":"Ramona Bledea","orcid":"0000-0001-6233-3327","position":3,"is_corresponding":false},{"id":398138,"name":"Ruple Jairath","orcid":"0000-0002-1896-5295","position":4,"is_corresponding":false},{"id":581766,"name":"Yang Wang","orcid":"0000-0001-7805-2861","position":5,"is_corresponding":false},{"id":249271,"name":"Matthew T. Patrick","orcid":"0000-0002-6174-9002","position":6,"is_corresponding":false},{"id":581768,"name":"Ryan A. Wilcox","orcid":"0000-0002-6420-0760","position":7,"is_corresponding":false},{"id":581767,"name":"Alexandra C. Hristov","orcid":"0000-0002-1836-6591","position":8,"is_corresponding":false},{"id":12819,"name":"Lam C. Tsoi","orcid":"0000-0003-1627-5722","position":9,"is_corresponding":false},{"id":581769,"name":"Trilokraj Tejasvi","orcid":"0000-0002-8186-8711","position":10,"is_corresponding":false},{"id":325773,"name":"Neil Jairath","orcid":"0000-0003-2317-169X","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:57.469517Z","pmid":"36383618","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}