{"doi":"10.1371/journal.pone.0276596","title":"Virological suppression among gay, bisexual, and other men who have sex with men living with HIV in Vancouver, Canada: A longitudinal cohort study from 2012–2017","abstract":"INTRODUCTION: In 2010, British Columbia (BC) implemented HIV Treatment as Prevention (TasP) as policy. We examined trends in virologic suppression and determinants of significant viremia among a prospective biobehavioural cohort of men who have sex with men (gbMSM) in Vancouver from 2012-2017. METHODS: Respondent-driven sampling was used to recruit sexually active gbMSM (≥16 years) who completed biannual study visits with a computer-assisted self-interview and clinical CD4 and viral load (VL) testing. We linked participant data with the BC HIV Drug Treatment Program to obtain antiretroviral dispensing and VL data. We conducted a trend analysis of VL suppression using univariable generalized estimating equation (GEE) multi-level modelling and multivariable GEE to identify factors associated with episodes of VL ≥200 copies/mL. RESULTS: Of 774 participants, 223 were living with HIV at baseline and 16 were diagnosed during follow-up (n = 239). We observed a significant trend towards reduced levels of unsuppressed VL (>200 copies/mL) from 22% (07/2012-12/2012) to 12% (07/2016-12/2016) (OR:0.87; 95%CI:0.83-0.91 for each 6-month period). Among those with at least one follow-up visit, (n = 178, median follow-up = 3.2 years, median age = 46.9 years), younger age (aOR:0.97; 95%CI:0.94-0.99, per year), ecstasy use (aOR:1.69; 95%CI:1.13-2.53), crystal methamphetamine use (aOR:1.71; 95%CI:1.18-2.48), seeking sex via websites (aOR:1.46; 95%CI:1.01-2.12), and lower HIV treatment optimism (aOR:0.94; 95%CI:0.90-0.97) were associated with episodes of elevated viremia. CONCLUSIONS: During a period when TasP policy was actively promoted, we observed a significant trend towards reduced levels of unsuppressed VL. Continued efforts should promote HIV treatment optimism and engagement, especially among younger gbMSM and those who use ecstasy and crystal methamphetamine.","journal":"PLoS ONE","year":2022,"id":279891,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8758,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":953941,"name":"Julian Gitelman","orcid":"0000-0003-0052-5520","position":1,"is_corresponding":false},{"id":711428,"name":"Zishan Cui","orcid":"0000-0002-9236-3890","position":2,"is_corresponding":false},{"id":954400,"name":"Nicanor Bacani","orcid":null,"position":3,"is_corresponding":false},{"id":437629,"name":"Paul Sereda","orcid":"0000-0002-6411-8089","position":4,"is_corresponding":false},{"id":751021,"name":"Nathan J. Lachowsky","orcid":"0000-0002-6336-8780","position":5,"is_corresponding":false},{"id":751020,"name":"Kiffer G. Card","orcid":"0000-0001-6545-1249","position":6,"is_corresponding":false},{"id":445647,"name":"Jordan M. Sang","orcid":"0000-0001-5649-0326","position":7,"is_corresponding":false},{"id":326323,"name":"H. Fisher Raymond","orcid":"0000-0001-8621-2749","position":8,"is_corresponding":false},{"id":12032,"name":"Julio Montaner","orcid":"0000-0002-6201-9829","position":9,"is_corresponding":false},{"id":953942,"name":"David Hall","orcid":"0000-0002-6675-5241","position":10,"is_corresponding":false},{"id":954401,"name":"Terry Lee Howard","orcid":null,"position":11,"is_corresponding":false},{"id":433755,"name":"Mark Hull","orcid":"0000-0002-9234-3531","position":12,"is_corresponding":false},{"id":340151,"name":"Robert S. Hogg","orcid":"0000-0003-3463-5488","position":13,"is_corresponding":false},{"id":953943,"name":"Eric Abella Roth","orcid":"0000-0002-9128-0997","position":14,"is_corresponding":false},{"id":953944,"name":"David Moore","orcid":"0000-0003-1078-9247","position":15,"is_corresponding":false},{"id":953940,"name":"Heather L. Armstrong","orcid":"0000-0002-1071-8644","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T00:28:59.341002Z","pmid":"36269767","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}