{"doi":"10.1371/journal.pone.0271310","title":"Predictors of chronic COVID-19 symptoms in a community-based cohort of adults","abstract":"BACKGROUND: COVID-19 can cause some individuals to experience chronic symptoms. Rates and predictors of chronic COVID-19 symptoms are not fully elucidated. OBJECTIVE: To examine occurrence and patterns of post-acute sequelae of SARS-CoV2 infection (PASC) symptomatology and their relationship with demographics, acute COVID-19 symptoms and anti-SARS-CoV-2 IgG antibody responses. METHODS: A multi-stage observational study was performed of adults (≥18 years) from 5 US states. Participants completed two rounds of electronic surveys (May-July 2020; April-May 2021) and underwent testing to anti-SARS-CoV-2 nucleocapsid protein IgG antibody testing. Latent Class Analysis was used to identify clusters of chronic COVID-19 symptoms. RESULTS: Overall, 390 adults (median [25%ile, 75%ile] age: 42 [31, 54] years) with positive SARS-CoV-2 antibodies completed the follow-up survey; 92 (24.7%) had ≥1 chronic COVID-19 symptom, with 11-month median duration of persistent symptoms (range: 1-12 months). The most common chronic COVID-19 symptoms were fatigue (11.3%), change in smell (9.5%) or taste (5.6%), muscle or joint aches (5.4%) and weakness (4.6%). There were significantly higher proportions of ≥1 persistent COVID-19 symptom (31.5% vs. 18.6%; Chi-square, P = 0.004), and particularly fatigue (15.8% vs. 7.3%, P = 0.008) and headaches (5.4% vs. 1.0%, P = 0.011) in females compared to males. Chronic COVID-19 symptoms were also increased in individuals with ≥6 acute COVID-19 symptoms, Latent class analysis revealed 4 classes of symptoms. Latent class-1 (change of smell and taste) was associated with lower anti-SARS-CoV-2 antibody levels; class-2 and 3 (multiple chronic symptoms) were associated with higher anti-SARS-CoV-2 antibody levels and more severe acute COVID-19 infection. LIMITATIONS: Ambulatory cohort with less severe acute disease. CONCLUSION: Individuals with SARS-CoV-2 infection commonly experience chronic symptoms, most commonly fatigue, changes in smell or taste and muscle/joint aches. Female sex, severity of acute COVID-19 infection, and higher anti-SARS-CoV-2 IgG levels were associated with the highest risk of having chronic COVID-19 symptoms.","journal":"PLoS ONE","year":2022,"id":260053,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8703,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":760868,"name":"Israel Zyskind","orcid":"0000-0003-3422-9631","position":1,"is_corresponding":false},{"id":760869,"name":"Hiam Naiditch","orcid":"0000-0003-4349-5309","position":2,"is_corresponding":false},{"id":913152,"name":"Jason Zimmerman","orcid":"0000-0001-7372-1376","position":3,"is_corresponding":false},{"id":291356,"name":"Aaron E. Glatt","orcid":"0000-0002-4018-900X","position":4,"is_corresponding":false},{"id":287964,"name":"Abraham Pinter","orcid":"0000-0002-3262-3304","position":5,"is_corresponding":false},{"id":227346,"name":"Elitza S. Theel","orcid":"0000-0002-6886-2294","position":6,"is_corresponding":false},{"id":7712,"name":"Michael J. Joyner","orcid":"0000-0002-7135-7643","position":7,"is_corresponding":false},{"id":371703,"name":"D. Ashley Hill","orcid":"0000-0003-1067-3922","position":8,"is_corresponding":false},{"id":761477,"name":"Miriam Lieberman","orcid":null,"position":9,"is_corresponding":false},{"id":761478,"name":"Elliot Bigajer","orcid":null,"position":10,"is_corresponding":false},{"id":761479,"name":"Daniel Stok","orcid":null,"position":11,"is_corresponding":false},{"id":761480,"name":"Elliot Frank","orcid":null,"position":12,"is_corresponding":false},{"id":235991,"name":"Avi Z. Rosenberg","orcid":"0000-0003-2356-950X","position":13,"is_corresponding":false},{"id":267764,"name":"Jonathan I. Silverberg","orcid":"0000-0003-3686-7805","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T00:26:03.189798Z","pmid":"35925904","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}