{"doi":"10.1371/journal.pone.0270889","title":"Delirium and its association with short-term outcomes in younger and older patients with acute heart failure","abstract":"Younger patients (18 to 65 years old) are often excluded from delirium outcome studies. We sought to determine if delirium was associated with short-term adverse outcomes in a diverse cohort of younger and older patients with acute heart failure (AHF). We conducted a multi-center prospective cohort study that included adult emergency department patients with confirmed AHF. Delirium was ascertained using the Brief Confusion Assessment Method (bCAM). The primary outcome was a composite outcome of 30-day all-cause death, 30-day all-cause rehospitalization, and prolonged index hospital length of stay. Multivariable logistic regression was performed, adjusting for demographics, cognitive impairment without delirium, and HF risk factors. Older age (≥ 65 years old)*delirium interaction was also incorporated into the model. Odds ratios (OR) with their 95% confidence intervals (95%CI) were reported. A total of 1044 patients with AHF were enrolled; 617 AHF patients were < 65 years old and 427 AHF patients were ≥ 65 years old, and 47 (7.6%) and 40 (9.4%) patients were delirious at enrollment, respectively. Delirium was significantly associated with the composite outcome (adjusted OR = 1.64, 95%CI: 1.02 to 2.64). The older age*delirium interaction p-value was 0.47. In conclusion, delirium was common in both younger and older patients with AHF and was associated with poorer short-term outcomes in both cohorts. Younger patients with acute heart failure should be included in future delirium outcome studies.","journal":"PLoS ONE","year":2022,"id":271031,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9363,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":500529,"name":"Candace D. McNaughton","orcid":"0000-0003-0095-9134","position":1,"is_corresponding":false},{"id":106000,"name":"William B. Stubblefield","orcid":"0000-0003-3817-1414","position":2,"is_corresponding":false},{"id":331879,"name":"Peter S. Pang","orcid":"0000-0003-3444-2811","position":3,"is_corresponding":false},{"id":331877,"name":"Phillip D. Levy","orcid":"0000-0001-7306-5620","position":4,"is_corresponding":false},{"id":294041,"name":"Karen F. Miller","orcid":"0000-0003-3126-5530","position":5,"is_corresponding":false},{"id":832577,"name":"Sarah Meram","orcid":null,"position":6,"is_corresponding":false},{"id":936429,"name":"Mette Cole","orcid":null,"position":7,"is_corresponding":false},{"id":240238,"name":"Cathy A. Jenkins","orcid":"0000-0001-7217-2985","position":8,"is_corresponding":false},{"id":801772,"name":"Hadassah H. Paz","orcid":"0000-0001-5390-0393","position":9,"is_corresponding":false},{"id":936430,"name":"Kelly Moser","orcid":null,"position":10,"is_corresponding":false},{"id":16594,"name":"Alan B. Storrow","orcid":"0000-0002-2893-808X","position":11,"is_corresponding":false},{"id":16593,"name":"Sean P. Collins","orcid":"0000-0002-2305-9836","position":12,"is_corresponding":false},{"id":729984,"name":"Jin H. Han","orcid":"0000-0003-0384-210X","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"35881580","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}