{"doi":"10.1371/journal.pone.0268508","title":"Automatic reagent handling and assay processing of human biospecimens inside a transportation container for a medical disaster response against radiation","abstract":"Biological materials can be shipped off-site for diagnostic, therapeutic and research purposes. They usually are kept in certain environments for their final application during transportation. However, active reagent handling during transportation from a collection site to a laboratory or biorepository has not been reported yet. In this paper, we show the application of a micro-controlled centrifugal microfluidic system inside a shipping container that can add reagent to an actively cultured human blood sample during transportation to ensure a rapid biodosimetry of cytokinesis-block micronucleus (CBMN) assay. The newly demonstrated concept could have a significant impact on rapid biodosimetry triage for medical countermeasure in a radiological disaster. It also opens a new capability in accelerated sample processing during transportation for biomedical and healthcare applications.","journal":"PLoS ONE","year":2022,"id":293742,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":799979,"name":"Jian Gu","orcid":"0000-0001-6081-9155","position":1,"is_corresponding":false},{"id":799980,"name":"Brett Duane","orcid":"0000-0001-9670-0594","position":2,"is_corresponding":false},{"id":978763,"name":"Alan Norquist","orcid":null,"position":3,"is_corresponding":false},{"id":109052,"name":"David J. Brenner","orcid":"0000-0002-0926-1210","position":4,"is_corresponding":false},{"id":978764,"name":"Adarsh Ramakumar","orcid":null,"position":5,"is_corresponding":false},{"id":533080,"name":"Frédéric Zenhausern","orcid":"0000-0001-8360-9118","position":6,"is_corresponding":false},{"id":978762,"name":"Adam Akkad","orcid":null,"position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T00:30:53.818562Z","pmid":"35594269","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}