{"doi":"10.1371/journal.pone.0268237","title":"An adaptive, asymptomatic SARS-CoV-2 workforce screening program providing real-time, actionable monitoring of the COVID-19 pandemic","abstract":"COVID-19 remains a challenge worldwide, and testing of asymptomatic individuals remains critical to pandemic control measures. Starting March 2020, a total of 7497 hospital employees were tested at least weekly for SARS CoV-2; the cumulative incidence of asymptomatic infections was 5.64%. Consistently over a 14-month period half of COVID-19 infections (414 of 820, total) were detected through the asymptomatic screening program, a third of whom never developed any symptoms during follow-up. Prompt detection and isolation of these cases substantially reduced the risk of potential workplace and outside of workplace transmission. COVID-19 vaccinations of the workforce were initiated in December 2020. Twenty-one individuals tested positive after being fully vaccinated (3.9 per 1000 vaccinated). Most (61.9%) remained asymptomatic and in majority (75%) the virus could not be sequenced due to low template RNA levels in swab samples. Further routine testing of vaccinated asymptomatic employees was stopped and will be redeployed if needed; routine testing for those not vaccinated continues. Asymptomatic SARS-CoV-2 testing, as a part of enhanced screening, monitors local dynamics of the COVID-19 pandemic and can provide valuable data to assess the ongoing impact of COVID-19 vaccination and SARS-CoV-2 variants, inform risk mitigation, and guide adaptive, operational planning including titration of screening strategies over time, based on infection risk modifiers such as vaccination.","journal":"PLoS ONE","year":2022,"id":290004,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9153,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":439781,"name":"James M. Hoffman","orcid":"0000-0002-2625-7766","position":1,"is_corresponding":false},{"id":618938,"name":"Li Tang","orcid":"0009-0007-3391-6655","position":2,"is_corresponding":false},{"id":242112,"name":"Stacey Schultz‐Cherry","orcid":"0000-0002-2021-727X","position":3,"is_corresponding":false},{"id":225737,"name":"Paul G. Thomas","orcid":"0000-0001-7955-0256","position":4,"is_corresponding":false},{"id":423505,"name":"Hana Hakim","orcid":"0000-0001-7146-5452","position":5,"is_corresponding":false},{"id":105444,"name":"Richard J. Webby","orcid":"0000-0002-4397-7132","position":6,"is_corresponding":false},{"id":302049,"name":"Randall T. Hayden","orcid":"0000-0002-3073-4115","position":7,"is_corresponding":false},{"id":614922,"name":"Aditya H. Gaur","orcid":"0000-0002-6639-5231","position":8,"is_corresponding":false},{"id":972480,"name":"St. Jude COVID-19 Employee Screening Program Team","orcid":null,"position":9,"is_corresponding":false},{"id":423504,"name":"Diego R. Hijano","orcid":"0000-0002-2903-666X","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T00:30:26.667578Z","pmid":"35522615","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}