{"doi":"10.1371/journal.pone.0267853","title":"Establishing a framework towards monitoring HCV microelimination among men who have sex with men living with HIV in Germany: A modeling analysis","abstract":"BACKGROUND: Prior to direct-acting antivirals (DAAs), HCV incidence rose among men who have sex with men (MSM) living with HIV infection in Germany despite high hepatitis C virus (HCV) treatment rates. We establish a HCV elimination modeling framework to evaluate whether existing treatment rates can achieve the World Health Organization (WHO) incidence target among MSM living with HIV in Germany. METHODS: To evaluate progress towards HCV elimination in Germany, we adapted a previously published HCV transmission model among MSM living with diagnosed HIV. We modelled HCV incidence and prevalence until 2030 (relative to 2015) under existing treatment and DAA scale-up and explored potential impacts of disruptions in treatment and behavioral risk reduction due to the COVID-19 pandemic. RESULTS: Continuing current treatment rates will result in stable HCV incidence among MSM living with HIV in Germany between 2015-2030. The WHO HCV incidence target is achievable under DAA scale-up to 100% treatment combined with treatment of those previously diagnosed and untreated (at a rate of 15%/year) and would result in greater reductions with early treatment (3 vs 6 months) reducing incidence from 4.0/100person-years to 0.8/100person-years by 2030. A 12-month disruption to HCV treatment (20% reduction) and risk behaviors (25%,50%,75% reduction) during the COVID-19 pandemic would result in a 15% relative increase in total HCV incidence in 2030 compared to that expected under the status quo. CONCLUSIONS: HCV elimination among MSM living with HIV in Germany requires further DAA scale-up among those newly diagnosed combined with efforts to treat those previously diagnosed but untreated. Prospective monitoring will establish whether Germany is on track for HCV microelimination.","journal":"PLoS ONE","year":2022,"id":284951,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503544,"name":"Patrick Ingiliz","orcid":"0000-0001-7218-4548","position":1,"is_corresponding":false},{"id":791866,"name":"Christoph Boesecke","orcid":"0000-0003-0686-6537","position":2,"is_corresponding":false},{"id":963122,"name":"Ivanka Krznaric","orcid":"0000-0001-9672-9661","position":3,"is_corresponding":false},{"id":963593,"name":"Knud Schewe","orcid":null,"position":4,"is_corresponding":false},{"id":664994,"name":"Thomas A. Lutz","orcid":"0000-0002-5056-8548","position":5,"is_corresponding":false},{"id":12050,"name":"Stefan Mauss","orcid":"0009-0007-2657-3738","position":6,"is_corresponding":false},{"id":963594,"name":"Stefan Christensen","orcid":null,"position":7,"is_corresponding":false},{"id":28609,"name":"Jürgen K. Rockstroh","orcid":"0000-0003-2858-3888","position":8,"is_corresponding":false},{"id":264448,"name":"Sonia Jain","orcid":"0000-0001-8408-1247","position":9,"is_corresponding":false},{"id":233617,"name":"Feng He","orcid":"0000-0003-0276-3303","position":10,"is_corresponding":false},{"id":69677,"name":"Joel O. Wertheim","orcid":"0000-0003-4882-5856","position":11,"is_corresponding":false},{"id":409491,"name":"Natasha K. Martin","orcid":"0000-0001-8344-1810","position":12,"is_corresponding":false},{"id":422573,"name":"Lara K Marquez","orcid":"0000-0003-0386-2936","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35551326","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}