{"doi":"10.1371/journal.pone.0266410","title":"SARS-CoV-2 seroprevalence among healthcare workers","abstract":"BACKGROUND: Monitoring COVID-19 infection risk among health care workers (HCWs) is a public health priority. We examined the seroprevalence of SARS-CoV-2 among HCWs following the fall infection surge in Minnesota, and before and after COVID-19 vaccination. Additionally, we assessed demographic and occupational risk factors for SARS-CoV-2 infection. METHODS: We conducted two rounds of seroprevalence testing among a cohort of HCWs: samples in round 1 were collected from 11/22/20-02/21/21 and in round 2 from 12/18/20-02/15/21. Demographic and occupational exposures assessed with logistic regression were age, sex, healthcare role and setting, and number of children in the household. The primary outcome was SARS-CoV-2 IgG seropositivity. A secondary outcome, SARS-CoV-2 infection, included both seropositivity and self-reported SARS-CoV-2 test positivity. RESULTS: In total, 459 HCWs were tested. 43/454 (9.47%) had a seropositive sample 1 and 75/423 (17.7%) had a seropositive sample 2. By time of sample 2 collection, 54% of participants had received at least one vaccine dose and seroprevalence was 13% among unvaccinated individuals. Relative to physicians, the odds of SARS-CoV-2 infection in other roles were increased (Nurse Practitioner: OR[95%CI] 1.93[0.57,6.53], Physician's Assistant: 1.69[0.38,7.52], Nurse: 2.33[0.94,5.78], Paramedic/EMTs: 3.86[0.78,19.0], other: 1.68[0.58,4.85]). The workplace setting was associated with SARS-CoV-2 infection (p = 0.04). SARS-CoV-2 seroprevalence among HCWs reporting duties in the ICU vs. those working in an ambulatory clinic was elevated: OR[95%CI] 2.17[1.01,4.68]. CONCLUSIONS: SARS-CoV-2 seroprevalence in HCW increased during our study period which was consistent with community infection rates. HCW role and setting-particularly working in the ICU-is associated with higher risk for SARS-CoV-2 infection.","journal":"PLoS ONE","year":2022,"id":251146,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9257,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271770,"name":"Bruno Bohn","orcid":"0000-0001-8961-6968","position":1,"is_corresponding":false},{"id":389077,"name":"Angela K. Ulrich","orcid":"0000-0002-4360-9719","position":2,"is_corresponding":false},{"id":754996,"name":"Steven D. Stovitz","orcid":"0000-0002-4168-9823","position":3,"is_corresponding":false},{"id":737924,"name":"Ali J. Strickland","orcid":null,"position":4,"is_corresponding":false},{"id":755532,"name":"Brianna M. Naumchik","orcid":null,"position":5,"is_corresponding":false},{"id":766519,"name":"Sara Walsh","orcid":null,"position":6,"is_corresponding":false},{"id":797033,"name":"Stephen M. Smith","orcid":"0000-0002-9158-6136","position":7,"is_corresponding":false},{"id":809782,"name":"Brett Baumgartner","orcid":null,"position":8,"is_corresponding":false},{"id":103434,"name":"Susan Kline","orcid":"0000-0001-7954-2926","position":9,"is_corresponding":false},{"id":809285,"name":"Stephanie Yendell","orcid":"0000-0001-9511-5553","position":10,"is_corresponding":false},{"id":809286,"name":"Craig W. Hedberg","orcid":"0000-0002-3203-9634","position":11,"is_corresponding":false},{"id":813249,"name":"Timothy J. Beebe","orcid":"0000-0003-4700-2436","position":12,"is_corresponding":false},{"id":36326,"name":"Ryan T. Demmer","orcid":"0000-0003-3429-0379","position":13,"is_corresponding":false},{"id":700879,"name":"Talia D. Wiggen","orcid":"0000-0002-5234-3238","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:24:37.429628Z","pmid":"35468153","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}