{"doi":"10.1371/journal.pone.0266168","title":"Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults","abstract":"There is limited evidence on the effects of environmental exposure to arsenic (As) on the immune system in adults. In a population-based study, we have found that urinary As (UAs), and its metabolites [inorganic As (InAs), monomethylated arsenicals (MMA+3/+5), and dimethylated arsenicals (DMA+3/+5)] modulate or influence the number of T-helper 17 (Th17) cells and IL-17A cytokine production. In non-smoking women, we observed that UAs and DMA+3/+5 were associated with changes in Th17 cell numbers in a nonlinear fashion. In smoking males, we found that UAs was associated with a significant decrease of Th17 cell numbers. Similar association was observed among non-smoking males. Likewise, UAs, DMA+3/+5 and MMA+3/+5 were associated with diminished production of IL-17A among non-smoking males. When stratified by Vitamin D levels defined as sufficient (≥20 ng/ml) and insufficient (<20 ng/ml), we found a substancial decrease in Th17 cell numbers among those with insufficient levels. Individuals with sufficient VitD levels demonstrated significant inhibition of IL-17A production in non-smoking males. Collectively, we find that exposure to As via drinking water is associated with alterations in Th17 numbers and IL-17A production, and that these associations may be modified by Vitamin D status. Our findings have significance for health outcomes associated with As exposure.","journal":"PLoS ONE","year":2022,"id":276444,"datarank":0.47000691014066487,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.14042322354023193,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.14042322354023193,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":true,"deposit_databanks":{"figshare":["10.6084/m9.figshare.17316374"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":423746,"name":"Fredine T. Lauer","orcid":"0000-0002-5460-4606","position":1,"is_corresponding":false},{"id":288771,"name":"Pam Factor‐Litvak","orcid":"0000-0002-7729-1884","position":2,"is_corresponding":false},{"id":373572,"name":"Tariqul Islam","orcid":"0000-0003-1623-5210","position":3,"is_corresponding":false},{"id":425139,"name":"Mahbubul Eunus","orcid":null,"position":4,"is_corresponding":false},{"id":425140,"name":"Md. Abu Horayara","orcid":null,"position":5,"is_corresponding":false},{"id":425142,"name":"Mizanour Rahman","orcid":null,"position":6,"is_corresponding":false},{"id":548552,"name":"Golam Sarwar","orcid":"0000-0002-7935-8093","position":7,"is_corresponding":false},{"id":226942,"name":"Habibul Ahsan","orcid":"0000-0001-9808-377X","position":8,"is_corresponding":false},{"id":425143,"name":"Joseph H. Graziano","orcid":null,"position":9,"is_corresponding":false},{"id":388893,"name":"Scott W. Burchiel","orcid":"0000-0001-9509-0149","position":10,"is_corresponding":false},{"id":373570,"name":"Faruque Parvez","orcid":"0000-0002-5079-3825","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:28:30.709588Z","pmid":"35404942","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}