{"doi":"10.1371/journal.pone.0256676","title":"Association between early gestation passive smoke exposure and neonatal size among self-reported non-smoking women by race/ethnicity: A cohort study","abstract":"Understanding implications of passive smoke exposure during pregnancy is an important public health issue under the Developmental Origins of Health and Disease paradigm. In a prospective cohort of low-risk non-smoking pregnant women (NICHD Fetal Growth Studies-Singletons, 2009-2013, N = 2055), the association between first trimester passive smoke exposure and neonatal size was assessed by race/ethnicity. Plasma biomarker concentrations (cotinine, nicotine) assessed passive smoke exposure. Neonatal anthropometric measures included weight, 8 non-skeletal, and 2 skeletal measures. Linear regression evaluated associations between continuous biomarker concentrations and neonatal anthropometric measures by race/ethnicity. Cotinine concentrations were low and the percent above limit of quantification varied by maternal race/ethnicity (10% Whites; 14% Asians; 15% Hispanics; 49% Blacks). The association between cotinine concentration and infant weight differed by race/ethnicity (Pinteraction = 0.034); compared to women of the same race/ethnicity, per 1 log-unit increase in cotinine, weight increased 48g (95%CI -44, 139) in White and 51g (95%CI -81, 183) in Hispanic women, but decreased -90g (95%CI -490, 309) in Asian and -93g (95%CI -151, -35) in Black women. Consistent racial/ethnic differences and patterns were found for associations between biomarker concentrations and multiple non-skeletal measures for White and Black women (Pinteraction<0.1). Among Black women, an inverse association between cotinine concentration and head circumference was observed (-0.20g; 95%CI -0.38, -0.02). Associations between plasma cotinine concentration and neonatal size differed by maternal race/ethnicity, with increasing concentrations associated with decreasing infant size among Black women, who had the greatest biomarker concentrations. Public health campaigns should advocate for reducing pregnancy exposure, particularly for vulnerable populations.","journal":"PLoS ONE","year":2021,"id":207058,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256216,"name":"Rajeshwari Sundaram","orcid":"0000-0002-6918-5002","position":1,"is_corresponding":false},{"id":291976,"name":"Germaine M. Buck Louis","orcid":"0000-0002-1774-4490","position":2,"is_corresponding":false},{"id":436755,"name":"Nicole Gerlanc","orcid":null,"position":3,"is_corresponding":false},{"id":475277,"name":"Alaina M. Bever","orcid":"0000-0003-3004-8497","position":4,"is_corresponding":false},{"id":291977,"name":"Kurunthachalam Kannan","orcid":"0000-0002-1926-7456","position":5,"is_corresponding":false},{"id":660368,"name":"Morgan Robinson","orcid":"0000-0002-2171-4905","position":6,"is_corresponding":false},{"id":292673,"name":"Melissa M. Smarr","orcid":"0000-0002-4347-405X","position":7,"is_corresponding":false},{"id":703297,"name":"Dian He","orcid":"0000-0003-0550-6249","position":8,"is_corresponding":false},{"id":285199,"name":"Fasil Tekola‐Ayele","orcid":"0000-0003-4194-9370","position":9,"is_corresponding":false},{"id":291978,"name":"Cuilin Zhang","orcid":"0000-0002-8014-2708","position":10,"is_corresponding":false},{"id":271560,"name":"Katherine L. Grantz","orcid":"0000-0003-0276-8534","position":11,"is_corresponding":false},{"id":475278,"name":"Melissa Amyx","orcid":"0000-0003-4660-7716","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:51:45.688025Z","pmid":"34793459","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}