{"doi":"10.1371/journal.pone.0245024","title":"An immunotoxin targeting Ebola virus glycoprotein inhibits Ebola virus production from infected cells","abstract":"Ebola virus (EBOV), a member of the mononegaviral family Filoviridae, causes severe disease associated with high lethality in humans. Despite enormous progress in development of EBOV medical countermeasures, no anti-EBOV treatment has been approved. We designed an immunotoxin in which a single-chain variable region fragment of the EBOV glycoprotein-specific monoclonal antibody 6D8 was fused to the effector domains of Pseudomonas aeruginosa exotoxin A (PE38). This immunotoxin, 6D8-PE38, bound specifically to cells expressing EBOV glycoproteins. Importantly, 6D8-PE38 targeted EBOV-infected cells, as evidenced by inhibition of infectious EBOV production from infected cells, including primary human macrophages. The data presented here provide a proof of concept for immunotoxin-based targeted killing of infected cells as a potential antiviral intervention for Ebola virus disease.","journal":"PLoS ONE","year":2021,"id":207210,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":745152,"name":"Shuǐqìng Yú","orcid":"0000-0002-9473-566X","position":1,"is_corresponding":false},{"id":792749,"name":"Xiǎolì Chī","orcid":null,"position":2,"is_corresponding":false},{"id":325396,"name":"Sheli R. Radoshitzky","orcid":"0000-0001-8976-8056","position":3,"is_corresponding":false},{"id":109882,"name":"Jens H. Kuhn","orcid":"0000-0002-7800-6045","position":4,"is_corresponding":false},{"id":381836,"name":"Edward A. Berger","orcid":"0000-0001-8457-3997","position":5,"is_corresponding":false},{"id":440220,"name":"Yíngyún Caì","orcid":"0000-0002-1101-0920","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T23:51:45.688025Z","pmid":"33411835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}