{"doi":"10.1371/journal.pone.0238070","title":"Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells","abstract":"Factors regulating self-antigen directed immune-responses in autoimmunity are poorly understood. Signal regulatory protein gamma (SIRPγ) is a human T-cell specific protein with genetic variants associated with type 1 diabetes (T1D). SIRPγ's function in the immune system remains unclear. We show that T1D and relapsing remitting multiple sclerosis (RRMS) subjects have significantly greater frequency of rs2281808 T genetic variant, that correlates with reduced SIRPγ-expression in T-cells. Importantly, reduced SIRPγ-expression in RRMS and T1D subjects was not restricted to T variant, suggesting SIRPγ-expression is also regulated by disease specific factors in autoimmunity. Interestingly, increased frequencies of SIRPγlow T-cells in RRMS and T1D positively correlated with proinflammatory molecules from T-cells. Finally, we show that SIRPγlow T-cells have enhanced pathogenecity in vivo in a GVHD model. These findings suggest that decreased-SIRPγ expression, either determined by genetic variants or through peripherally acquired processes, may have a mechanistic link to autoimmunity through induction of hyperactive T-cells.","journal":"PLoS ONE","year":2020,"id":72971,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9686,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384614,"name":"Pranav S. Renavikar","orcid":"0009-0006-4226-2633","position":1,"is_corresponding":false},{"id":386208,"name":"Michael P. Crawford","orcid":null,"position":2,"is_corresponding":false},{"id":384615,"name":"Scott Steward-Tharp","orcid":"0000-0002-5865-4539","position":3,"is_corresponding":false},{"id":386209,"name":"Ashley A. Brate","orcid":null,"position":4,"is_corresponding":false},{"id":384616,"name":"Eva Tsalikian","orcid":"0000-0003-3429-2796","position":5,"is_corresponding":false},{"id":384617,"name":"Michael Tansey","orcid":"0000-0002-8157-8423","position":6,"is_corresponding":false},{"id":386210,"name":"Ezzatollah T. Shivapour","orcid":null,"position":7,"is_corresponding":false},{"id":384618,"name":"Tracey Cho","orcid":"0000-0002-6208-1489","position":8,"is_corresponding":false},{"id":386211,"name":"John Kamholz","orcid":null,"position":9,"is_corresponding":false},{"id":384619,"name":"Nitin J. Karandikar","orcid":"0000-0002-6867-6950","position":10,"is_corresponding":false},{"id":361245,"name":"Sushmita Sinha","orcid":"0000-0003-3385-1023","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T21:45:32.034078Z","pmid":"32853219","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}