{"doi":"10.1371/journal.pone.0233693","title":"Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission","abstract":"Efavirenz-based first-line regimens have been widely used for children ≥3 years of age starting antiretroviral therapy, despite possible resistance with prior exposure to non-nucleoside reverse transcriptase inhibitors for prevention of mother-to-child transmission (PMTCT). We used logistic regression to examine the association between PMTCT exposure and viral failure (VF) defined as two consecutive viral loads (VL)>1000 copies/ml between 6-18 months on ART. Children with previous nevirapine exposure for PMTCT were not at higher risk of VF compared to unexposed children (adjusted Odds Ratio (aOR): 0.79; 95% CI:0.56, 1.11).","journal":"PLoS ONE","year":2020,"id":129748,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":110157,"name":"Mary‐Ann Davies","orcid":"0000-0001-8496-6475","position":1,"is_corresponding":false},{"id":346852,"name":"Karl‐Günter Technau","orcid":"0000-0001-7367-7512","position":2,"is_corresponding":false},{"id":315057,"name":"Geoffrey Fatti","orcid":"0000-0002-6467-662X","position":3,"is_corresponding":false},{"id":328863,"name":"Helena Rabie","orcid":"0000-0001-6336-2963","position":4,"is_corresponding":false},{"id":39224,"name":"Frank Tanser","orcid":"0000-0001-9797-0000","position":5,"is_corresponding":false},{"id":110156,"name":"Andrew Boulle","orcid":"0000-0002-7713-8062","position":6,"is_corresponding":false},{"id":252299,"name":"Robin Wood","orcid":"0000-0002-4276-7117","position":7,"is_corresponding":false},{"id":542919,"name":"Brian Eley","orcid":"0000-0003-0811-0098","position":8,"is_corresponding":false},{"id":361252,"name":"Shobna Sawry","orcid":"0000-0002-3845-4863","position":9,"is_corresponding":false},{"id":542920,"name":"Janet Giddy","orcid":"0000-0002-1316-8078","position":10,"is_corresponding":false},{"id":559189,"name":"Nosisa Sipambo","orcid":"0000-0003-0058-6884","position":11,"is_corresponding":false},{"id":346847,"name":"Louise Kuhn","orcid":"0000-0002-2305-8665","position":12,"is_corresponding":false},{"id":473780,"name":"Lee Fairlie","orcid":"0000-0001-5327-1734","position":13,"is_corresponding":false},{"id":581413,"name":"Patience Nyakato","orcid":"0000-0002-8418-8500","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-18T23:15:49.682497Z","pmid":"32469985","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}