{"doi":"10.1371/journal.pone.0231360","title":"Intraocular pressure reduction in a pigmentary glaucoma model by Goniotome Ab interno trabeculectomy","abstract":"PURPOSE: To investigate whether microsurgical excision of trabecular meshwork (TM) in an ex vivo pigmentary glaucoma model can normalize the hypertensive phenotype. METHODS: Eight eyes of a porcine pigmentary glaucoma model underwent 90° of microsurgical TM excision with an aspirating dual-blade (Goniotome (G)). 24 hours later, additional 90° of TM were removed. Anterior segments with sham surgeries served as the control (C). Outflow facility and intraocular pressure (IOP) were analyzed. Histology with hematoxylin and eosin (H&E) was obtained. RESULTS: After the first 90° TM excision, IOP was significantly lower in G (10.2±2.4 mmHg, n = 7) than C (20.0±2.0mmHg, n = 8, P<0.01). Outflow facility in G (0.38±0.07 μl/min/mmHg) was higher than C (0.16±0.02 μl/min/mmHg, P<0.01). After the second 90° TM excision, IOP in G (6.46±0.81 mmHg, n = 7) was significantly lower than C (20.3±1.7 mmHg, n = 8, P<0.001), while the outflow facility in G (0.50±0.05 μl/min/mmHg, n = 7) was higher than C (0.16±0.01 μl/min/mmHg, n = 8, P<0.001). Compared to the first excision, excision of an additional 90° did not change of IOP (P = 0.20) or outflow facility (P = 0.17) further. CONCLUSIONS: Excision of 90° of TM in a pigmentary glaucoma model using an aspirating dual-blade decreased IOP and increased outflow facility.","journal":"PLoS ONE","year":2020,"id":81699,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9606,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":422236,"name":"Yalong Dang","orcid":"0000-0003-2194-6375","position":1,"is_corresponding":false},{"id":422237,"name":"Priyal Shah","orcid":"0000-0002-1623-6355","position":2,"is_corresponding":false},{"id":422238,"name":"Hamed Esfandiari","orcid":"0000-0001-7301-7047","position":3,"is_corresponding":false},{"id":422239,"name":"Ying Hong","orcid":"0000-0003-4000-9539","position":4,"is_corresponding":false},{"id":403617,"name":"Ralitsa T. Loewen","orcid":null,"position":5,"is_corresponding":false},{"id":402689,"name":"Susannah Waxman","orcid":"0000-0001-6708-3187","position":6,"is_corresponding":false},{"id":402691,"name":"Sarah Atta","orcid":"0000-0002-4175-6504","position":7,"is_corresponding":false},{"id":402895,"name":"Xiaobo Xia","orcid":"0000-0002-2785-3391","position":8,"is_corresponding":false},{"id":402692,"name":"Nils A. Loewen","orcid":"0000-0001-7167-1213","position":9,"is_corresponding":false},{"id":402690,"name":"Chao Wang","orcid":"0000-0002-9764-4341","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:52:58.921847Z","pmid":"32298335","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}