{"doi":"10.1371/journal.pone.0229461","title":"Evaluation of antiviral T cell responses and TSCM cells in volunteers enrolled in a phase I HIV-1 subtype C prophylactic vaccine trial in India","abstract":"T cells play an important role in controlling viral replication during HIV infection. An effective vaccine should, therefore, lead to the induction of a strong and early viral-specific CD8+ T cell response. While polyfunctional T cell responses are thought to be important contributors to the antiviral response, there is evidence to show that polyfunctional HIV- specific CD8+ T cells are just a small fraction of the total HIV-specific CD8+ T cells and may be absent in many individuals who control HIV replication, suggesting that other HIV-1 specific CD8+ effector T cell subsets may be key players in HIV control. Stem cell-like memory T cells (TSCM) are a subset of T cells with a long half-life and self-renewal capacity. They serve as key reservoirs for HIV and contribute a significant barrier to HIV eradication. The present study evaluated vaccine-induced antiviral responses and TSCM cells in volunteers vaccinated with a subtype C prophylactic HIV-1 vaccine candidate administered in a prime-boost regimen. We found that ADVAX DNA prime followed by MVA boost induced significantly more peripheral CD8+ TSCM cells and higher levels of CD8+ T cell-mediated inhibition of replication of different HIV-1 clades as compared to MVA alone and placebo. These findings are novel and provide encouraging evidence to demonstrate the induction of TSCM and cytotoxic immune responses by a subtype C HIV-1 prophylactic vaccine administered using a prime-boost strategy.","journal":"PLoS ONE","year":2020,"id":85159,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":435955,"name":"Peter Hayes","orcid":"0000-0002-1251-934X","position":1,"is_corresponding":false},{"id":435956,"name":"Natalia Fernández","orcid":"0000-0002-4213-079X","position":2,"is_corresponding":false},{"id":307493,"name":"Kannan Thiruvengadam","orcid":"0000-0002-3758-1094","position":3,"is_corresponding":false},{"id":436921,"name":"Sathyamurthi Pattabiram","orcid":null,"position":4,"is_corresponding":false},{"id":436922,"name":"Manohar Nesakumar","orcid":null,"position":5,"is_corresponding":false},{"id":435957,"name":"A. R. Srinivasan","orcid":"0000-0002-3272-9985","position":6,"is_corresponding":false},{"id":436923,"name":"Sujitha Kathirvel","orcid":null,"position":7,"is_corresponding":false},{"id":436924,"name":"Janani Shankar","orcid":null,"position":8,"is_corresponding":false},{"id":435958,"name":"Rajat Goyal","orcid":"0000-0001-5702-0932","position":9,"is_corresponding":false},{"id":436925,"name":"Nikhil Singla","orcid":null,"position":10,"is_corresponding":false},{"id":435959,"name":"Joyeeta Mukherjee","orcid":"0009-0000-5018-2736","position":11,"is_corresponding":false},{"id":436926,"name":"Shweta Chatrath","orcid":null,"position":12,"is_corresponding":false},{"id":322284,"name":"Jill Gilmour","orcid":null,"position":13,"is_corresponding":false},{"id":436927,"name":"Sudha Subramanyam","orcid":null,"position":14,"is_corresponding":false},{"id":435960,"name":"Srikanth Tripathy","orcid":"0000-0002-8363-2606","position":15,"is_corresponding":false},{"id":22837,"name":"Soumya Swaminathan","orcid":"0009-0004-2233-7250","position":16,"is_corresponding":false},{"id":326398,"name":"Luke Elizabeth Hanna","orcid":"0000-0002-6299-8211","position":17,"is_corresponding":false},{"id":435954,"name":"Sivasankaran Munusamy Ponnan","orcid":"0000-0001-6705-4474","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T21:56:02.794896Z","pmid":"32097435","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}