{"doi":"10.1371/journal.pone.0227263","title":"Effects of remote limb ischemic conditioning on muscle strength in healthy young adults: A randomized controlled trial","abstract":"Remote limb ischemic conditioning (RLIC) is a clinically feasible method in which brief, sub-lethal bouts of ischemia protects remote organs or tissues from subsequent ischemic injury. A single session of RLIC can improve exercise performance and increase muscle activation. The purpose of this study, therefore, was to assess the effects of a brief, two-week protocol of repeated RLIC combined with strength training on strength gain and neural adaptation in healthy young adults. Participants age 18-40 years were randomized to receive either RLIC plus strength training (n = 15) or sham conditioning plus strength training (n = 15). Participants received RLIC or sham conditioning over 8 visits using a blood pressure cuff on the dominant arm with 5 cycles of 5 minutes each alternating inflation and deflation. Visits 3-8 paired conditioning with wrist extensors strength training on the non-dominant (non-conditioned) arm using standard guidelines. Changes in one repetition maximum (1 RM) and electromyography (EMG) amplitude were compared between groups. Both groups were trained at a similar workload. While both groups gained strength over time (P = 0.001), the RLIC group had greater strength gains (9.38 ± 1.01 lbs) than the sham group (6.3 ± 1.08 lbs, P = 0.035). There was not a significant group x time interaction in EMG amplitude (P = 0.231). The RLIC group had larger percent changes in 1 RM (43.8% vs. 26.1%, P = 0.003) and EMG amplitudes (31.0% vs. 8.6%, P = 0.023) compared to sham conditioning. RLIC holds promise for enhancing muscle strength in healthy young and older adults, as well as clinical populations that could benefit from strength training.","journal":"PLoS ONE","year":2020,"id":98974,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":279005,"name":"Marghuretta D. Bland","orcid":"0000-0001-9091-2764","position":1,"is_corresponding":false},{"id":487919,"name":"Anna E. Mattlage","orcid":"0000-0003-1900-7344","position":2,"is_corresponding":false},{"id":369364,"name":"Ling Chen","orcid":"0000-0003-0238-1831","position":3,"is_corresponding":false},{"id":468266,"name":"Jeffrey M. Gidday","orcid":"0000-0002-4641-0465","position":4,"is_corresponding":false},{"id":310715,"name":"Jin‐Moo Lee","orcid":"0000-0002-3979-0906","position":5,"is_corresponding":false},{"id":285667,"name":"Tamara Hershey","orcid":"0000-0001-7549-0698","position":6,"is_corresponding":false},{"id":279001,"name":"Catherine E. Lang","orcid":"0000-0002-7120-0136","position":7,"is_corresponding":false},{"id":378824,"name":"Swati M. Surkar","orcid":"0000-0002-3334-4892","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-18T22:37:35.547042Z","pmid":"32017777","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}