{"doi":"10.1371/journal.pone.0227093","title":"Use of GeneXpert and the role of an expert panel in improving clinical diagnosis of smear-negative tuberculosis cases","abstract":null,"journal":"PLOS ONE","year":2019,"id":595450,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1210285,"name":"Victoria Dalay","orcid":null,"position":1,"is_corresponding":false},{"id":1524810,"name":"Ivor Langley","orcid":null,"position":2,"is_corresponding":false},{"id":1524811,"name":"Ewan Tomeny","orcid":null,"position":3,"is_corresponding":false},{"id":1210274,"name":"Danaida Marcelo","orcid":null,"position":4,"is_corresponding":false},{"id":1524813,"name":"Victor Mendoza","orcid":null,"position":5,"is_corresponding":false},{"id":1524816,"name":"Arvin Christian Aquino","orcid":"0000-0002-4544-7821","position":6,"is_corresponding":false},{"id":924555,"name":"Anna Marie Celina Garfin","orcid":"0000-0003-3793-2429","position":7,"is_corresponding":false},{"id":1524818,"name":"Bertie Squire","orcid":null,"position":8,"is_corresponding":false},{"id":799543,"name":"Charles Yu","orcid":null,"position":9,"is_corresponding":false},{"id":1524806,"name":"Jovilia Abong","orcid":"0000-0003-4220-1495","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Use of GeneXpert and the role of an expert panel in improving clinical diagnosis of smear-negative tuberculosis cases","abstract":"SETTING: A high proportion of notified tuberculosis cases in the Philippines are clinically diagnosed (63%) as opposed to bacteriologically confirmed. Better understanding of this phenomenon is required to improve tuberculosis control. OBJECTIVES: To determine the percentage of smear negative presumptive tuberculosis patients that would be diagnosed by GeneXpert; compare clinical characteristics of patients diagnosed as tuberculosis cases; and review the impact that the current single government physician and a reconstituted Tuberculosis Diagnostic committee (expert panel) may have on tuberculosis over-diagnosis. DESIGN: This a cross-sectional study of 152 patients 15-85 years old with two negative Direct Sputum Smear Microscopy results, with abnormal chest X-ray who underwent GeneXpert testing and review by an expert panel. RESULTS: Thirty-two percent (48/152) of the sample were Xpert positive and 93% (97/104) of GeneXpert negatives were clinically diagnosed by a single physician. Typical symptoms and X-ray findings were higher in bacteriologically confirmed tuberculosis. When compared to the GeneXpert results the Expert panel's sensitivity for active tuberculosis was high (97.5%, 39/40), specificity was low (40.2%, 35/87). CONCLUSION: Using the GeneXpert would increase the level of bacteriologically confirmed tuberculosis substantially among presumptive tuberculosis. An expert panel will greatly reduce over-diagnosis usually seen when a decision is made by a single physician.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31887127","pmcid":"PMC6936841","openalex_id":"https://openalex.org/W2945588274","authors":[],"funders":[],"total_grants":0,"fwci":0.9486,"citation_percentile":0.72978219,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227093&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227093&type=printable","host_type":"publisher"},{"url":"https://dx.plos.org/10.1371/journal.pone.0227093","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0227093","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31887127","host_type":"repository"},{"url":"https://doaj.org/article/37197008092949b48d13d60f69608917","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6936841","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6936841","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6936841?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Tuberculosis Research and Epidemiology","Diagnosis and treatment of tuberculosis","Clinical Reasoning and Diagnostic Skills","Adolescent","Adult","Aged","Aged, 80 and over","Cross-Sectional Studies","DNA, Bacterial","Feasibility Studies","Female","Humans","Lung","Male","Middle Aged","Mycobacterium tuberculosis","Nucleic Acid Amplification Techniques","Philippines","Pulmonologists","Radiography","Sputum","Tuberculosis, Pulmonary","Young Adult"],"mesh_terms":["Pulmonologists","Adolescent","Adult","Aged","Aged, 80 and over","Cross-Sectional Studies","DNA, Bacterial","Expert Testimony","Feasibility Studies","Female","Humans","Lung","Male","Middle Aged","Mycobacterium tuberculosis","Philippines","Radiography","Sputum","Tuberculosis, Pulmonary","Nucleic Acid Amplification Techniques","Young Adult"],"keywords":["GeneXpert MTB/RIF","Tuberculosis","Medicine","Sputum","Tuberculosis diagnosis","Internal medicine","Mycobacterium tuberculosis","Surgery","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T17:28:04.149207Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}