{"doi":"10.1371/journal.pone.0226856","title":"Hipk is required for JAK/STAT activity during development and tumorigenesis","abstract":null,"journal":"PLOS ONE","year":2019,"id":606111,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555799,"name":"Jessica A. Blaquiere","orcid":null,"position":1,"is_corresponding":false},{"id":1555800,"name":"Nathan B. Wray","orcid":null,"position":2,"is_corresponding":false},{"id":426021,"name":"Esther M. Verheyen","orcid":"0000-0002-9795-5094","position":3,"is_corresponding":false},{"id":138123,"name":"Gritta Tettweiler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hipk is required for JAK/STAT activity during development and tumorigenesis","abstract":"Drosophila has been instrumental as a model system in studying signal transduction and revealing molecular functions in development and human diseases. A point mutation in the Drosophila Janus kinase JAK (called hop) causes constitutive activation of the JAK/STAT pathway. We provide robust genetic evidence that the Homeodomain interacting protein kinase (Hipk) is required for endogenous JAK/STAT activity. Overexpression of Hipk can phenocopy the effects of overactive JAK/STAT mutations and lead to melanized tumors, and loss of Hipk can suppress the effects of hyperactive JAK/STAT. Further, the loss of the pathway effector Stat92E can suppress Hipk induced overgrowth. Interaction studies show that Hipk can physically interact with Stat92E and regulate Stat92E subcellular localization. Together our results show that Hipk is a novel factor required for effective JAK/STAT signaling.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31891940","pmcid":"PMC6938406","openalex_id":"https://openalex.org/W2998564252","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"RGPIN/2014-05479","title":null},{"funder_name":"NIH HHS","grant_id":"P40 OD018537","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"},{"funder_name":"National Institutes of Health","grant_id":"3P40OD018537-04S1","title":"Bloomington Drosophila Stock Center at Indiana University"}],"total_grants":4,"fwci":1.1032,"citation_percentile":0.74859143,"influential_citations":0,"citation_trend":[{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226856&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226856&type=printable","host_type":"publisher"},{"url":"https://dx.plos.org/10.1371/journal.pone.0226856","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0226856","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31891940","host_type":"repository"},{"url":"https://doaj.org/article/ad506790507e4263b650b85aee591117","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6938406","host_type":"repository"},{"url":"https://figshare.com/articles/Hipk_is_required_for_JAK_STAT_activity_during_development_and_tumorigenesis/11486157","host_type":"repository"},{"url":"http://summit.sfu.ca/item/19576","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6938406","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6938406?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0226856","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0226856","host_type":""},{"url":"https://summit.sfu.ca/item/19576","host_type":""}],"fields_of_study":["Hippo pathway signaling and YAP/TAZ","Kruppel-like factors research","Cytokine Signaling Pathways and Interactions","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Carcinogenesis","Drosophila Proteins","Drosophila melanogaster","Gene Expression Regulation, Developmental","Gene Expression Regulation, Neoplastic","Janus Kinases","Protein Kinases","Transcription Factors"],"mesh_terms":["Animals","Drosophila melanogaster","Protein Kinases","Transcription Factors","Gene Expression Regulation, Neoplastic","Gene Expression Regulation, Developmental","Drosophila Proteins","Janus Kinases","Carcinogenesis"],"keywords":["stat","JAK-STAT signaling pathway","Janus kinase","STAT4","Phenocopy","Biology","Cell biology","Signal transduction","SOCS3","Cancer research","Effector","Carcinogenesis","STAT3","Genetics","Phenotype","Gene","Tyrosine kinase","Science","Q","R","Gene Expression Regulation, Developmental","Gene Expression Regulation, Neoplastic","Drosophila melanogaster","Medicine","Animals","Drosophila Proteins","Protein Kinases","Research Article","Janus Kinases","Transcription Factors"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:54:41.378543Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}