{"doi":"10.1371/journal.pone.0226138","title":"In vivo elongation of thin filaments results in heart failure","abstract":"A novel cardiac-specific transgenic mouse model was generated to identify the physiological consequences of elongated thin filaments during post-natal development in the heart. Remarkably, increasing the expression levels in vivo of just one sarcomeric protein, Lmod2, results in ~10% longer thin filaments (up to 26% longer in some individual sarcomeres) that produce up to 50% less contractile force. Increasing the levels of Lmod2 in vivo (Lmod2-TG) also allows us to probe the contribution of Lmod2 in the progression of cardiac myopathy because Lmod2-TG mice present with a unique cardiomyopathy involving enlarged atrial and ventricular lumens, increased heart mass, disorganized myofibrils and eventually, heart failure. Turning off of Lmod2 transgene expression at postnatal day 3 successfully prevents thin filament elongation, as well as gross morphological and functional disease progression. We show here that Lmod2 has an essential role in regulating cardiac contractile force and function.","journal":"PLoS ONE","year":2020,"id":68863,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364696,"name":"Gerrie P. Farman","orcid":"0000-0001-8095-8179","position":1,"is_corresponding":false},{"id":364697,"name":"Rachel M. Mayfield","orcid":"0000-0003-1015-1147","position":2,"is_corresponding":false},{"id":364698,"name":"Joshua Strom","orcid":"0000-0003-1236-1877","position":3,"is_corresponding":false},{"id":364699,"name":"Miensheng Chu","orcid":"0000-0002-8262-5834","position":4,"is_corresponding":false},{"id":364700,"name":"Christopher T. Pappas","orcid":"0000-0002-7475-6949","position":5,"is_corresponding":false},{"id":364701,"name":"Carol C. Gregorio","orcid":"0000-0002-0044-2074","position":6,"is_corresponding":false},{"id":364695,"name":"Lei Mi‐Mi","orcid":"0000-0002-8595-0552","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T21:41:52.279368Z","pmid":"31899774","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}