{"doi":"10.1371/journal.pone.0191517","title":"Effects of six common dietary nutrients on murine intestinal organoid growth","abstract":null,"journal":"PLOS ONE","year":2018,"id":657726,"datarank":1.5459899955371978,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":1.00035207157824,"self_endowment_contribution":0.5456379239589579,"citer_contribution":1.00035207157824,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":36,"citers_with_citation_signal":33,"citers_with_endowment":33,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1334140,"name":"Yijun Qi","orcid":"0000-0002-7100-1700","position":1,"is_corresponding":false},{"id":1716957,"name":"Albert Jergens","orcid":null,"position":2,"is_corresponding":false},{"id":1716958,"name":"Michael Wannemuehler","orcid":null,"position":3,"is_corresponding":false},{"id":309352,"name":"Terrence A. Barrett","orcid":"0000-0001-6428-3271","position":4,"is_corresponding":false},{"id":451289,"name":"Qun Wang","orcid":"0000-0002-5660-5602","position":5,"is_corresponding":false},{"id":1716955,"name":"Tenson Cai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of six common dietary nutrients on murine intestinal organoid growth","abstract":"The intestinal epithelium of the gastrointestinal (GI) tract constantly renews itself to absorb nutrients and provide protection for the body from the outside world. Since the intestinal epithelium is constantly exposed to various chemicals and dietary components, it is critical to determine which constituents promote or inhibit intestinal epithelium health and growth rate. Intestinal organoids, three-dimensional miniature models of the intestines, represent an ex vivo tool to investigate intestinal physiology and growth patterns. In this study, we measured the growth rates of murine intestinal organoids exposed to various concentrations of different dietary constituents. Results indicate that caffeic acid inhibited organoid growth in a concentration-dependent manner, curcumin exhibited variable effectiveness, and vitamin C had no effect on organoid growth.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29389993","pmcid":"PMC5794098","openalex_id":"https://openalex.org/W2791879416","authors":[],"funders":[{"funder_name":"Crohn’s and Colitis Foundation of America","grant_id":"No. 348137","title":null},{"funder_name":"Directorate for Engineering","grant_id":"No. EEC 1560012","title":null},{"funder_name":"Pharmaceutical Research and Manufacturers of America Foundation","grant_id":"No. RSGTMT17","title":null},{"funder_name":"VA Merit","grant_id":"I01CX001353","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01DK095662","title":null},{"funder_name":"NIH HHS","grant_id":"2RO1 DK095662 ","title":null},{"funder_name":"Crohn's & Colitis Foundation","grant_id":"348137","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R01DK095662-10A1","title":"The Role of Crypt Fissioning in IBD Ulcer Healing"},{"funder_name":"National Institutes of Health","grant_id":"5I01CX001353-02","title":"The role of Axin2+ stem cells in ulcer healing during colitis."}],"total_grants":9,"fwci":1.1521,"citation_percentile":0.81480086,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":5},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":3},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0191517&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0191517&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0191517","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0191517","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29389993","host_type":"repository"},{"url":"https://uknowledge.uky.edu/internalmedicine_facpub/146","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5794098","host_type":"repository"},{"url":"https://doaj.org/article/9082037e63fa41a3b5574f7cc00db850","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5794098","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5794098?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0191517","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0191517","host_type":""},{"url":"https://doi.org/https://doi.org/20.500.12876/nrQBLj0z","host_type":""},{"url":"https://doi.org/https://doi.org/10.1371/journal.pone.0191517","host_type":""}],"fields_of_study":["Cancer Cells and Metastasis","0301 basic medicine","03 medical and health sciences","0303 health sciences","Animals","Ascorbic Acid","Caffeic Acids","Chlorogenic Acid","Coumaric Acids","Curcumin","Diet","Gastrointestinal Tract","Mice","Sodium Glutamate","Stem Cells"],"mesh_terms":["Animals","Ascorbic Acid","Caffeic Acids","Chlorogenic Acid","Coumaric Acids","Curcumin","Diet","Sodium Glutamate","Stem Cells","Gastrointestinal Tract","Mice"],"keywords":["Organoid","Intestinal epithelium","Ex vivo","Gastrointestinal tract","Epithelium","Biology","Intestinal mucosa","Curcumin","Cell biology","Physiology","In vivo","Biochemistry","Internal medicine","Medicine","Biotechnology","570","Coumaric Acids","Science","610","Ascorbic Acid","and Tissue Engineering","Mice","Caffeic Acids","Sodium Glutamate","Animals","DegreeDisciplines::Medicine and Health Sciences::Medical Specialties::Gastroenterology","Stem Cells","Q","R","DegreeDisciplines::Engineering::Biomedical Engineering and Bioengineering::Molecular","Diet","DegreeDisciplines::Life Sciences::Nutrition","Cellular","Chlorogenic Acid","Research Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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