{"doi":"10.1371/journal.pone.0180996","title":"Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and meta-analysis","abstract":null,"journal":"PLOS ONE","year":2017,"id":675036,"datarank":0.6782682865573562,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"self_citation_contribution":0.6782682865573562,"citation_network_contribution":0.0,"self_endowment_contribution":0.6782682865573562,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":91,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1763752,"name":"Isaac Alobu","orcid":null,"position":1,"is_corresponding":false},{"id":23308,"name":"Kingsley Nnanna Ukwaja","orcid":"0000-0002-1974-8735","position":2,"is_corresponding":false},{"id":1763751,"name":"Cajetan C. Onyedum","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and meta-analysis","abstract":"BACKGROUND: Drug-resistant tuberculosis (TB) undermines control efforts and its burden is poorly understood in resource-limited settings. We performed a systematic review and meta-analysis to provide an up-to-date summary of the extent of drug-resistant TB in Nigeria. METHODS: We searched PubMed, Scopus, Embase, HINARI, AJOL, the Cochrane library, Web of Science, and Google Scholar for reports published before January 31 2017, that included any resistance, mono-resistance or multidrug resistance to anti-TB drugs in Nigeria. Summary estimates were calculated using random effects models. RESULTS: We identified 34 anti-TB drug resistance surveys with 8002 adult TB patients consisting of 2982 new and 5020 previously-treated cases. The prevalence rate of any drug resistance among new TB cases was 32.0% (95% CI 24.0-40.0%; 734/2892) and among previously-treated cases, the rate was 53.0% (95% CI 35.0-71.0%; 1467/5020). Furthermore, multidrug resistance among new and previously-treated cases was 6.0% (95% CI 4.0-8.0%;161/2502)and 32.0% (95%CI 20.0-44.0; 357/949), respectively. There was significant heterogeneity between the studies (p<0.001, I2 tests). The prevalence of drug-resistant TB varied according to methods of drug susceptibility testing and geographic region of Nigeria. CONCLUSION: The burden of drug-resistant TB in Nigeria is high. We recommend that a national anti-TB drug resistance survey be carried out, and strategies for case detection and programmatic management of drug-resistant TB in Nigeria need to be strengthened.","is_dataset_classified":null,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28704459","pmcid":"PMC5509256","openalex_id":"https://openalex.org/W2734338471","authors":[],"funders":[],"total_grants":0,"fwci":1.7134,"citation_percentile":0.81062356,"influential_citations":0,"citation_trend":[{"year":2018,"count":10},{"year":2019,"count":8},{"year":2020,"count":12},{"year":2021,"count":12},{"year":2022,"count":17},{"year":2023,"count":6},{"year":2024,"count":15},{"year":2025,"count":7},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180996&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180996&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0180996","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0180996","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28704459","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5509256","host_type":"repository"},{"url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180996","host_type":"repository"},{"url":"https://doaj.org/article/afd60530570d4724aac61900782a5038","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/Prevalence_of_drug-resistant_tuberculosis_in_Nigeria_A_systematic_review_and_meta-analysis/5205922","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5509256","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5509256?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Tuberculosis Research and Epidemiology","Diverse Scientific Research Studies","Healthcare Facilities Design and Sustainability","Adult","Antitubercular Agents","Humans","Nigeria","Prevalence","Risk Factors","Tuberculosis, Multidrug-Resistant"],"mesh_terms":["Adult","Antitubercular Agents","Humans","Nigeria","Risk Factors","Prevalence","Tuberculosis, Multidrug-Resistant"],"keywords":["Tuberculosis","Medicine","Drug resistance","Cochrane Library","Meta-analysis","Drug resistant tuberculosis","Drug","Extensively drug-resistant tuberculosis","Internal medicine","Web of science","Multiple drug resistance","Scopus","Multi-drug-resistant tuberculosis","MEDLINE","Veterinary medicine","Pharmacology","Mycobacterium tuberculosis","Pathology","Biology","Microbiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T19:27:53.165865Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}