{"doi":"10.1371/journal.pone.0167003","title":"Regulation and Maintenance of an Adoptive T-Cell Dependent Memory B Cell Pool","abstract":null,"journal":"PLOS ONE","year":2016,"id":650320,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1695612,"name":"Inês Amado","orcid":null,"position":1,"is_corresponding":false},{"id":1244091,"name":"Marie-Pierre Mailhé","orcid":null,"position":2,"is_corresponding":false},{"id":916249,"name":"Emmanuel Donnadieu","orcid":"0000-0002-4985-7254","position":3,"is_corresponding":false},{"id":930979,"name":"Sylvie Garcia","orcid":"0000-0002-7655-8911","position":4,"is_corresponding":false},{"id":632310,"name":"François Huetz","orcid":"0000-0001-8704-1881","position":5,"is_corresponding":false},{"id":1695613,"name":"Antonio A. 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The recall responses were more efficient if the antigenic boost was delayed suggesting that a period of adaptation is necessary before the transferred cells are able to respond. Overall these findings indicate that reconstitution of a functional and complete memory pool requires transfer of all different antigen-experienced B cell subsets. We also found that the size of the memory B cell pool did not rely on the number of the responding naïve B cells, suggesting autonomous homeostatic controls for naïve and memory B cells. By reconstituting a stable memory B cell pool in immune-deficient hosts using a monoclonal high-affinity B cell population we demonstrate the potential value of B cell adoptive immunotherapy.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27880797","pmcid":"PMC5120830","openalex_id":"https://openalex.org/W2549786100","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"AdG09 249740-QSIS","title":null},{"funder_name":"European Research Council","grant_id":"249740","title":"Role of Quorum Sensing mechanisms in the Immune System s regulation"},{"funder_name":"Institut Pasteur","grant_id":"","title":null},{"funder_name":"Centre National de la Recherche Scientifique","grant_id":"","title":null}],"total_grants":4,"fwci":0.2821,"citation_percentile":0.60989861,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":1},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167003&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167003&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0167003","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0167003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27880797","host_type":"repository"},{"url":"https://doaj.org/article/4ab9094f4e8c45a283114bc7eb5a1bb9","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5120830","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5120830","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5120830?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0167003","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0167003","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Immunotherapy and Immune Responses","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Antigens, Differentiation","Immunoglobulin G","Immunoglobulin M","Immunologic Memory","T-Lymphocytes","B-Lymphocyte Subsets","Mice, Knockout","Germinal Center","Mice"],"keywords":["Adoptive cell transfer","Germinal center","Memory B cell","B-1 cell","Naive B cell","B cell","Biology","Priming (agriculture)","Antigen","Immunology","Immune system","Population","Antibody","T cell","Cell biology","Antigen-presenting cell","Medicine","Mice, Knockout","Science","T-Lymphocytes","Q","R","B-Lymphocyte Subsets","Antigens, Differentiation","Mice","Immunoglobulin M","Immunoglobulin G","Animals","Immunologic Memory","Research Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T05:16:18.506008Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}