{"doi":"10.1371/journal.pone.0161470","title":"ABCB1 Overexpression Is a Key Initiator of Resistance to Tyrosine Kinase Inhibitors in CML Cell Lines","abstract":null,"journal":"PLOS ONE","year":2016,"id":600676,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":836095,"name":"Timothy P. Hughes","orcid":"0000-0002-0910-3730","position":1,"is_corresponding":false},{"id":864204,"name":"Deborah L. White","orcid":"0000-0003-4844-333X","position":2,"is_corresponding":false},{"id":1540020,"name":"Laura N. Eadie","orcid":"0000-0003-1912-7602","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"ABCB1 Overexpression Is a Key Initiator of Resistance to Tyrosine Kinase Inhibitors in CML Cell Lines","abstract":"The tyrosine kinase inhibitor (TKI) imatinib has resulted in excellent responses in the majority of Chronic Myeloid Leukaemia (CML) patients; however, resistance is observed in 20-30% of patients. More recently, resistance to the second generation TKIs, nilotinib and dasatinib, has also been observed albeit at a lower incidence. ABCB1 has previously been implicated in TKI export and its overexpression linked to TKI resistance. In this study the dynamics of nilotinib resistance was studied in CML cell lines with particular focus on ABCB1 expression levels during development of resistance. Results revealed ABCB1 overexpression is likely an important initiator of nilotinib resistance in vitro. ABCB1 overexpression was also observed in cell lines as an intermediate step during development of resistance to imatinib and dasatinib in vitro. We conclude that ABCB1 overexpression may provide an initial platform to facilitate development of additional mechanisms for resistance to TKIs. This provides a rationale for investigating this phenomenon in patients undergoing TKI therapy.","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27536777","pmcid":"PMC4990177","openalex_id":"https://openalex.org/W2514979974","authors":[],"funders":[{"funder_name":"Leukaemia Foundation","grant_id":"PhD Scholarship","title":null}],"total_grants":1,"fwci":3.6924,"citation_percentile":0.93583601,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":7},{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161470&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161470&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0161470","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0161470","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27536777","host_type":"repository"},{"url":"http://hdl.handle.net/2440/106610","host_type":"repository"},{"url":"https://doaj.org/article/a8f5522be0904d819ec39490e48726c8","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/ABCB1_Overexpression_Is_a_Key_Initiator_of_Resistance_to_Tyrosine_Kinase_Inhibitors_in_CML_Cell_Lines/3711264","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4990177","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4990177","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4990177?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Chronic Myeloid Leukemia Treatments","Chronic Lymphocytic Leukemia Research","Eosinophilic Disorders and Syndromes","ATP Binding Cassette Transporter, Subfamily B","Antineoplastic Agents","Blotting, Western","Cell Line, Tumor","Cell Survival","Dasatinib","Drug Resistance, Neoplasm","Flow Cytometry","Humans","Imatinib Mesylate","Inhibitory Concentration 50","Leukemia, Myelogenous, Chronic, BCR-ABL Positive","Protein-Tyrosine Kinases","Pyrimidines","Real-Time Polymerase Chain Reaction"],"mesh_terms":["Imatinib Mesylate","Dasatinib","Antineoplastic Agents","Cell Survival","Flow Cytometry","Humans","Protein-Tyrosine Kinases","Pyrimidines","Blotting, Western","Leukemia, Myelogenous, Chronic, BCR-ABL Positive","ATP Binding Cassette Transporter, Subfamily B","Drug Resistance, Neoplasm","Inhibitory Concentration 50","Cell Line, Tumor","Real-Time Polymerase Chain Reaction"],"keywords":["Nilotinib","Dasatinib","Tyrosine-kinase inhibitor","Imatinib","Tyrosine kinase","Cancer research","Medicine","Drug resistance","Imatinib mesylate","Pharmacology","Biology","Myeloid leukemia","Internal medicine","Genetics","Cancer","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T13:49:24.190963Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}