{"doi":"10.1371/journal.pone.0158959","title":"Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort","abstract":null,"journal":"PLOS ONE","year":2016,"id":599615,"datarank":0.5742962094733643,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.0,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1536730,"name":"Gunilla N. Fredrikson","orcid":null,"position":1,"is_corresponding":false},{"id":442280,"name":"Ulrika Ericson","orcid":"0000-0003-4629-4318","position":2,"is_corresponding":false},{"id":1536731,"name":"Bo Gullberg","orcid":null,"position":3,"is_corresponding":false},{"id":837559,"name":"Bo Hedblad","orcid":null,"position":4,"is_corresponding":false},{"id":34124,"name":"Gunnar Engström","orcid":"0000-0002-8618-9152","position":5,"is_corresponding":false},{"id":234992,"name":"Signe Borgquist","orcid":"0000-0001-7938-8893","position":6,"is_corresponding":false},{"id":108542,"name":"Jan Nilsson","orcid":"0000-0002-9752-7479","position":7,"is_corresponding":false},{"id":1536732,"name":"Elisabet Wirfält","orcid":null,"position":8,"is_corresponding":false},{"id":1536729,"name":"Joana A. Dias","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort.","abstract":"<h4>Objective</h4>Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association.<h4>Methods</h4>In the Malmö Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55-73 years at baseline (1991-96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31st, 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression.<h4>Results</h4>Inverse associations with breast cancer were seen in fully-adjusted models, for 2nd and 3rd tertiles of ox-LDL, OR (95% CI): 0.65 (0.47-0.90), 0.63 (0.45-0.89) respectively, p-trend = 0.01; and for the 3rd tertile of TNF-α, 0.65 (0.43-0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05-2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer.<h4>Conclusion</h4>Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27391324","pmcid":"PMC4938491","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0158959&type=printable","host_type":"publisher"},{"url":"https://figshare.com/articles/dataset/Low-Grade_Inflammation_Oxidative_Stress_and_Risk_of_Invasive_Post-Menopausal_Breast_Cancer_-_A_Nested_Case-Control_Study_from_the_Malm_Diet_and_Cancer_Cohort/3905385","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4938491","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4938491","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4938491?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Humans","Breast Neoplasms","Inflammation","Inflammation Mediators","Follow-Up Studies","Prospective Studies","Oxidative Stress","Postmenopause","Aged","Middle Aged","Sweden","Female","Biomarkers, Tumor"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T10:51:05.377902Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}