{"doi":"10.1371/journal.pone.0157153","title":"Natalizumab Therapy Modulates miR-155, miR-26a and Proinflammatory Cytokine Expression in MS Patients","abstract":null,"journal":"PLOS ONE","year":2016,"id":607073,"datarank":0.62147020895873,"base_score":4.143134726391533,"endowment":4.143134726391533,"self_citation_contribution":0.62147020895873,"citation_network_contribution":0.0,"self_endowment_contribution":0.62147020895873,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":62,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1558676,"name":"Giannina Arru","orcid":null,"position":1,"is_corresponding":false},{"id":1558677,"name":"Elisa Caggiu","orcid":null,"position":2,"is_corresponding":false},{"id":1558678,"name":"Magdalena Niegowska","orcid":null,"position":3,"is_corresponding":false},{"id":1558680,"name":"Stefania Leoni","orcid":null,"position":4,"is_corresponding":false},{"id":1558682,"name":"Giordano Madeddu","orcid":null,"position":5,"is_corresponding":false},{"id":1558684,"name":"Sergio Babudieri","orcid":null,"position":6,"is_corresponding":false},{"id":1558686,"name":"Gian Pietro Sechi","orcid":null,"position":7,"is_corresponding":false},{"id":1214479,"name":"Leonardo A. Sechi","orcid":"0000-0003-0566-2049","position":8,"is_corresponding":false},{"id":1558674,"name":"Giuseppe Mameli","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Natalizumab Therapy Modulates miR-155, miR-26a and Proinflammatory Cytokine Expression in MS Patients","abstract":"MicroRNAs fine-tune the regulation of Th1/Th17 lymphocyte subsets in multiple sclerosis. We investigated the expression of miRNAs (previously associated with mycobacterial and viral infections) in MS patients and healthy donors (HD) following 6 months natalizumab therapy. In addition, Th1/Th17 cytokines and the presence of anti-EBNA1/VCA IgG in MS patients with different pattern of miRNA expression have been evaluated. MiR-155, miR-26a, miR-132, miR-146a and Th1/Th17 cytokines expression was detected by RT-real time PCR; moreover anti-EBNA1 and VCA IgG titres were measured by ELISA. We observed an up-regulation of miR-155 (p value = 0.009) and miR-132 (p value = 0.04) in MS patients compared to HD. In MS patients, IL-17a (p = 0.037), IFN γ (p = 0.012) and TNFα (p = 0.015) but not IL-6 were over-expressed compared to HD. Two different miRNAs patterns associated to the expression of different cytokines were observed in the MS cohort. Moreover, a down-regulation of miR-155 and miR-26a was seen in MS patients during and after natalizumab therapy. MS patients that over-expressed miR-155 showed a higher EBNA1 IgG titer than MS patients with high levels of miR-26a. In conclusions the expression of particular miRNAs modulates the pro-inflammatory cytokine expression and the humoral response against EBV and this expression is natalizumab regulated.","is_dataset_classified":null,"base_score":4.143134726391533,"endowment":4.143134726391533,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27310932","pmcid":"PMC4911163","openalex_id":"https://openalex.org/W2428365123","authors":[],"funders":[{"funder_name":"FISM","grant_id":"(grant number Cod. 2013/R/15","title":null},{"funder_name":"Regione autonoma della Sardegna","grant_id":"2010 CRP 25160","title":null}],"total_grants":2,"fwci":5.0365,"citation_percentile":0.95710834,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2017,"count":3},{"year":2018,"count":8},{"year":2019,"count":8},{"year":2020,"count":7},{"year":2021,"count":11},{"year":2022,"count":7},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0157153&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0157153&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0157153","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0157153","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27310932","host_type":"repository"},{"url":"https://doaj.org/article/70473aa485204c739c2b43afbe90010b","host_type":"repository"},{"url":"http://eprints.uniss.it/11324/1/Mameli_G_Natalizumab_therapy_modulates_miR155.pdf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4911163","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4911163","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4911163?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Multiple Sclerosis Research Studies","Polyomavirus and related diseases","MicroRNA in disease regulation"],"mesh_terms":["Natalizumab","Adult","Female","Gene Expression Regulation","Humans","Immunoglobulin G","Male","Middle Aged","Multiple Sclerosis","Tumor Necrosis Factor-alpha","Interleukin-6","Cytokines","Epstein-Barr Virus Nuclear Antigens","Interleukin-17","MicroRNAs"],"keywords":["Natalizumab","Multiple sclerosis","Proinflammatory cytokine","microRNA","Immunology","Cytokine","miR-155","Medicine","Biology","Inflammation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T05:43:23.036073Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}