{"doi":"10.1371/journal.pone.0137711","title":"Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation","abstract":null,"journal":"PLOS ONE","year":2015,"id":13800,"datarank":0.3732886378640539,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.06137240661207849,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.06137240661207849,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":111714,"name":"Mei Zhao","orcid":null,"position":1,"is_corresponding":false},{"id":111715,"name":"Bolan Yu","orcid":null,"position":2,"is_corresponding":false},{"id":111716,"name":"Chuan Bai","orcid":null,"position":3,"is_corresponding":false},{"id":111717,"name":"Zhaofeng Huang","orcid":null,"position":4,"is_corresponding":false},{"id":111713,"name":"Qingfeng Ding","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26368822","pmcid":"PMC4569406","openalex_id":"https://openalex.org/W2231494303","authors":[],"funders":[],"total_grants":0,"fwci":0.2777,"citation_percentile":0.60177661,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2021,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0137711&type=printable","host_type":"journal"},{"url":"https://doi.org/10.1371/journal.pone.0137711","host_type":"GOLD"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0137711&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0137711","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26368822","host_type":"repository"},{"url":"https://doaj.org/article/6184ad7831f94931b4091cc3c91568fe","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4569406","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4569406","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4569406?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Psoriasis: Treatment and Pathogenesis","IL-33, ST2, and ILC Pathways","Asthma and respiratory diseases","Biology","Medicine","Chemistry","Animals","Autoimmune Diseases","Aza Compounds","Cell Differentiation","Cell Line","Cell Survival","Drug Evaluation, Preclinical","HEK293 Cells","High-Throughput Screening Assays","Humans","Interleukin-17","Jurkat Cells","Mice","Nuclear Receptor Subfamily 1, Group F, Member 3","Small Molecule Libraries","Th17 Cells"],"mesh_terms":["Animals","Autoimmune Diseases","Aza Compounds","Cell Differentiation","Cell Line","Cell Survival","Drug Evaluation, Preclinical","Humans","Jurkat Cells","Interleukin-17","Mice","Small Molecule Libraries","Nuclear Receptor Subfamily 1, Group F, Member 3","High-Throughput Screening Assays","HEK293 Cells","Th17 Cells"],"keywords":["RAR-related orphan receptor gamma","Jurkat cells","Orphan receptor","Interleukin 17","Retinoic acid","Cellular differentiation","Chemistry","T cell","Cell biology","Transcription factor","Biology","Pharmacology","Immunology","Cytokine","Biochemistry","Immune system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-05-31T17:01:13.411803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}