{"doi":"10.1371/journal.pone.0134142","title":"Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model","abstract":null,"journal":"PLOS ONE","year":2015,"id":588514,"datarank":2.91598748869012,"base_score":4.770684624465665,"endowment":4.770684624465665,"self_citation_contribution":0.7156026936698499,"citation_network_contribution":2.2003847950202697,"self_endowment_contribution":0.7156026936698499,"citer_contribution":2.2003847950202697,"corpus_percentile":null,"corpus_rank":null,"citation_count":117,"citer_count":117,"citers_with_citation_signal":109,"citers_with_endowment":109,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513884,"name":"Wenjie Wei","orcid":"0000-0002-1720-1808","position":1,"is_corresponding":false},{"id":1505596,"name":"Marta A. Gaertig","orcid":null,"position":2,"is_corresponding":false},{"id":297204,"name":"Shihua Li","orcid":"0000-0003-1775-6536","position":3,"is_corresponding":false},{"id":141898,"name":"Xiao-Jiang Li","orcid":null,"position":4,"is_corresponding":false},{"id":1505595,"name":"Wenxiao Jiang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model","abstract":"Huntington disease (HD) represents a family of neurodegenerative diseases that are caused by misfolded proteins. The misfolded proteins accumulate in the affected brain regions in an age-dependent manner to cause late-onset neurodegeneration. Transgenic mouse models expressing the HD protein, huntingtin, have been widely used to identify therapeutics that may retard disease progression. Here we report that Berberine (BBR), an organic small molecule isolated from plants, has protective effects on transgenic HD (N171-82Q) mice. We found that BBR can reduce the accumulation of mutant huntingtin in cultured cells. More importantly, when given orally, BBR could effectively alleviate motor dysfunction and prolong the survival of transgenic N171-82Q HD mice. We found that BBR could promote the degradation of mutant huntingtin by enhancing autophagic function. Since BBR is an orally-taken drug that has been safely used to treat a number of diseases, our findings suggest that BBR can be tested on different HD animal models and HD patients to further evaluate its therapeutic effects.","is_dataset_classified":null,"base_score":4.770684624465665,"endowment":4.770684624465665,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26225560","pmcid":"PMC4520448","openalex_id":"https://openalex.org/W1896472383","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS045016","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG019206","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS041669","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG031153","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS041669","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R56 AG019206","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG019206","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS036232","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS036232","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01NS019206-03","title":"VISUAL BEHAVIOR--ANATOMICAL AND FUNCTIONAL BASIS"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS041669-06","title":"Nuclear toxicity of Huntington disease protein"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS036232-19","title":"Neuronal function of huntingtin-associated protein"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG019206-03","title":"Synaptic toxicity of Huntington disease protein"}],"total_grants":13,"fwci":3.0336,"citation_percentile":0.91420813,"influential_citations":2,"citation_trend":[{"year":2016,"count":8},{"year":2017,"count":5},{"year":2018,"count":9},{"year":2019,"count":9},{"year":2020,"count":10},{"year":2021,"count":14},{"year":2022,"count":16},{"year":2023,"count":18},{"year":2024,"count":15},{"year":2025,"count":11},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134142&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134142&type=printable","host_type":"GOLD"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134142&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0134142","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0134142","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26225560","host_type":"repository"},{"url":"https://doaj.org/article/838556b9e1dd4c07bc9dc00c75910fcc","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4520448","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4520448","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4520448?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0134142","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0134142","host_type":""}],"fields_of_study":["Genetic Neurodegenerative Diseases","Berberine and alkaloids research","Autophagy in Disease and Therapy","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Autophagy","Behavior, Animal","Berberine","Disease Models, Animal","Humans","Huntington Disease","Mice, Transgenic","Mice","HEK293 Cells"],"keywords":["Huntingtin","Huntington's disease","Neurodegeneration","Genetically modified mouse","Transgene","Huntingtin Protein","Biology","Mutant","Disease","Pharmacology","Cell biology","Medicine","Biochemistry","Gene","Internal medicine","Behavior, Animal","Berberine","Science","Q","R","Mice, Transgenic","Disease Models, Animal","Mice","HEK293 Cells","Huntington Disease","Autophagy","Animals","Humans","Research Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-21T09:21:29.752954Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}