{"doi":"10.1371/journal.pone.0132291","title":"Vγ9Vδ2 T-Cell Polyfunctionality Is Differently Modulated in HAART-Treated HIV Patients according to CD4 T-Cell Count","abstract":null,"journal":"PLOS ONE","year":2015,"id":593081,"datarank":0.5900057451344376,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.23032145421468186,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.23032145421468186,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":9,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1517873,"name":"Gabriele De Simone","orcid":null,"position":1,"is_corresponding":false},{"id":240137,"name":"Alessandra Sacchi","orcid":"0000-0003-4964-386X","position":2,"is_corresponding":false},{"id":1517874,"name":"Alessandra Rinaldi","orcid":null,"position":3,"is_corresponding":false},{"id":290591,"name":"Domenico Viola","orcid":null,"position":4,"is_corresponding":false},{"id":228459,"name":"Chiara Agrati","orcid":"0000-0002-5252-0927","position":5,"is_corresponding":false},{"id":240138,"name":"Veronica Bordoni","orcid":"0000-0002-1747-2245","position":6,"is_corresponding":false},{"id":240139,"name":"Eleonora Cimini","orcid":"0000-0002-2659-0868","position":7,"is_corresponding":false},{"id":1517875,"name":"Nicola Tumino","orcid":null,"position":8,"is_corresponding":false},{"id":289772,"name":"Francesca Besi","orcid":"0000-0002-9401-300X","position":9,"is_corresponding":false},{"id":1517876,"name":"Federico Martini","orcid":null,"position":10,"is_corresponding":false},{"id":240141,"name":"Rita Casetti","orcid":"0000-0002-7574-8780","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Vγ9Vδ2 T-Cell Polyfunctionality Is Differently Modulated in HAART-Treated HIV Patients according to CD4 T-Cell Count","abstract":"Alteration of γδ T-cell distribution and function in peripheral blood is among the earliest defects during HIV-infection. We asked whether the polyfunctional response could also be affected, and how this impairment could be associated to CD4 T-cell count. To this aim, we performed a cross-sectional study on HIV-infected individuals. In order to evaluate the polyfunctional-Vγ9Vδ2 T-cell response after phosphoantigen-stimulation, we assessed the cytokine/chemokine production and cytotoxicity by flow-cytometry in HAART-treated-HIV+ persons and healthy-donors. During HIV-infection Vγ9Vδ2-polyfunctional response quality is affected, since several Vγ9Vδ2 T-cell subsets resulted significantly lower in HIV+ patients in respect to healthy donors. Interestingly, we found a weak positive correlation between Vγ9Vδ2 T-cell-response and CD4 T-cell counts. By dividing the HIV+ patients according to CD4 T-cell count, we found that Low-CD4 patients expressed a lower number of two Vγ9Vδ2 T-cell subsets expressing MIP-1β in different combinations with other molecules (CD107a/IFNγ) in respect to High-CD4 individuals. Our results show that the Vγ9Vδ2 T-cell-response quality in Low-CD4 patients is specifically affected, suggesting a direct link between innate Vγ9Vδ2 T-cells and CD4 T-cell count. These findings suggest that Vγ9Vδ2 T-cell quality may be indirectly influenced by HAART therapy and could be included in a new therapeutical strategy which would perform an important role in fighting HIV infection.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26161861","pmcid":"PMC4498914","openalex_id":"https://openalex.org/W793188790","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.00617561,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0132291&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0132291&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0132291","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0132291","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26161861","host_type":"repository"},{"url":"https://doaj.org/article/984f997c661f42fc94f2460efdeced30","host_type":"repository"},{"url":"http://hdl.handle.net/11590/400087","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4498914","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4498914","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4498914?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Immune Cell Function and Interaction","HIV Research and Treatment","T-cell and B-cell Immunology"],"mesh_terms":["Adult","Chronic Disease","Female","Flow Cytometry","Humans","Interferon-gamma","Male","CD4-Positive T-Lymphocytes","HIV Infections","T-Lymphocyte Subsets","Receptors, Antigen, T-Cell, gamma-delta","Lymphocyte Count","Antiretroviral Therapy, Highly Active","Adaptor Proteins, Signal Transducing","Lysosomal-Associated Membrane Protein 1"],"keywords":["Flow cytometry","T cell","Immunology","Medicine","Cell","Cd4 t cell","Chemokine","Biology","Immune system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T17:07:26.199095Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}