{"doi":"10.1371/journal.pone.0114520","title":"Comparison of Multiple Displacement Amplification (MDA) and Multiple Annealing and Looping-Based Amplification Cycles (MALBAC) in Single-Cell Sequencing","abstract":null,"journal":"PLoS ONE","year":2014,"id":601959,"datarank":0.6414999178524083,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":0.0,"self_endowment_contribution":0.6414999178524083,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":253790,"name":"Pengfei Song","orcid":"0000-0002-9103-6345","position":1,"is_corresponding":false},{"id":997986,"name":"Dan Zou","orcid":null,"position":2,"is_corresponding":false},{"id":95690,"name":"Xuesong Hu","orcid":"0000-0002-7135-520X","position":3,"is_corresponding":false},{"id":1543621,"name":"Shancen Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":13476,"name":"Shengjie Gao","orcid":null,"position":5,"is_corresponding":false},{"id":319789,"name":"Fei Ling","orcid":"0000-0002-1687-1519","position":6,"is_corresponding":false},{"id":1543620,"name":"Minfeng Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of Multiple Displacement Amplification (MDA) and Multiple Annealing and Looping-Based Amplification Cycles (MALBAC) in Single-Cell Sequencing","abstract":"Single-cell sequencing promotes our understanding of the heterogeneity of cellular populations, including the haplotypes and genomic variability among different generation of cells. Whole-genome amplification is crucial to generate sufficient DNA fragments for single-cell sequencing projects. Using sequencing data from single sperms, we quantitatively compare two prevailing amplification methods that extensively applied in single-cell sequencing, multiple displacement amplification (MDA) and multiple annealing and looping-based amplification cycles (MALBAC). Our results show that MALBAC, as a combination of modified MDA and tweaked PCR, has a higher level of uniformity, specificity and reproducibility.","is_dataset_classified":null,"base_score":4.276666119016055,"endowment":4.276666119016055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25485707","pmcid":"PMC4259343","openalex_id":"https://openalex.org/W2007692615","authors":[],"funders":[],"total_grants":0,"fwci":2.3396,"citation_percentile":0.88710908,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":3},{"year":2016,"count":7},{"year":2017,"count":7},{"year":2018,"count":12},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":8},{"year":2022,"count":7},{"year":2023,"count":6},{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114520&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114520&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0114520","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0114520","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25485707","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25875279","host_type":"repository"},{"url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114520","host_type":"repository"},{"url":"https://doaj.org/article/93fca549c62844f78cae50be05d3b884","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_Comparison_of_Multiple_Displacement_Amplification_MDA_and_Multiple_Annealing_and_Looping_Based_Amplification_Cycles_MALBAC_in_Single_Cell_Sequencing_/1265049","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4259343","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4395414","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4259343","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4259343?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Single-cell and spatial transcriptomics","Cancer Genomics and Diagnostics","Genomics and Phylogenetic Studies","Biomarkers","Genome, Human","Genomics","Humans","Male","Nucleic Acid Amplification Techniques","Polymorphism, Single Nucleotide","Sequence Analysis, DNA","Single-Cell Analysis","Spermatozoa"],"mesh_terms":["Humans","Male","Spermatozoa","Biomarkers","Genome, Human","Sequence Analysis, DNA","Polymorphism, Single Nucleotide","Nucleic Acid Amplification Techniques","Genomics","Single-Cell Analysis"],"keywords":["Multiple displacement amplification","Single cell sequencing","DNA sequencing","Biology","Polymerase chain reaction","Computational biology","Deep sequencing","Single-cell analysis","Molecular biology","Genetics","Genome","DNA","Cell","Exome sequencing","Gene","DNA extraction","Phenotype"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T17:53:52.928633Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}