{"doi":"10.1371/journal.pone.0101814","title":"Allergic Contact Dermatitis in Psoriasis Patients: Typical, Delayed, and Non-Interacting","abstract":"Psoriasis is characterized by an apoptosis-resistant and metabolic active epidermis, while a hallmark for allergic contact dermatitis (ACD) is T cell-induced keratinocyte apoptosis. Here, we induced ACD reactions in psoriasis patients sensitized to nickel (n = 14) to investigate underlying mechanisms of psoriasis and ACD simultaneously. All patients developed a clinically and histologically typical dermatitis upon nickel challenge even in close proximity to pre-existing psoriasis plaques. However, the ACD reaction was delayed as compared to non-psoriatic patients, with a maximum intensity after 7 days. Whole genome expression analysis revealed alterations in numerous pathways related to metabolism and proliferation in non-involved skin of psoriasis patients as compared to non-psoriatic individuals, indicating that even in clinically non-involved skin of psoriasis patients molecular events opposing contact dermatitis may occur. Immunohistochemical comparison of ACD reactions as well as in vitro secretion analysis of lesional T cells showed a higher Th17 and neutrophilic migration as well as epidermal proliferation in psoriasis, while ACD reactions were dominated by cytotoxic CD8+ T cells and a Th2 signature. Based on these findings, we hypothesized an ACD reaction directly on top of a pre-existing psoriasis plaque might influence the clinical course of psoriasis. We observed a strong clinical inflammation with a mixed psoriasis and eczema phenotype in histology. Surprisingly, the initial psoriasis plaque was unaltered after self-limitation of the ACD reaction. We conclude that sensitized psoriasis patients develop a typical, but delayed ACD reaction which might be relevant for patch test evaluation in clinical practice. Psoriasis and ACD are driven by distinct and independent immune mechanisms.","journal":"PLoS ONE","year":2014,"id":1689,"datarank":2.921899466305096,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":2.3685675481880057,"self_endowment_contribution":0.5533319181170905,"citer_contribution":2.3685675481880057,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":35,"citers_with_citation_signal":29,"citers_with_endowment":29,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0443,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2014-07-24","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1256,"name":"Stefanie  Eyerich","orcid":"0000-0002-1166-2355","position":1,"is_corresponding":false},{"id":19057,"name":"Bettina Knapp","orcid":null,"position":2,"is_corresponding":false},{"id":19058,"name":"Francesca Nasorri","orcid":null,"position":3,"is_corresponding":false},{"id":19059,"name":"Claudia Scarponi","orcid":"0000-0002-2323-8519","position":4,"is_corresponding":false},{"id":19060,"name":"Martina Mattii","orcid":null,"position":5,"is_corresponding":false},{"id":19061,"name":"Natalie Garzorz","orcid":null,"position":6,"is_corresponding":false},{"id":19062,"name":"Anna T. 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