{"doi":"10.1371/journal.pone.0096177","title":"Chinese Herbal Medicine Suppresses Invasion-Promoting Capacity of Cancer-Associated Fibroblasts in Pancreatic Cancer","abstract":null,"journal":"PLoS ONE","year":2014,"id":641947,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1184294,"name":"Chao Qu","orcid":"0000-0002-7655-6318","position":1,"is_corresponding":false},{"id":242218,"name":"Hao Chen","orcid":"0000-0002-8874-0673","position":2,"is_corresponding":false},{"id":1669366,"name":"Litao Xu","orcid":null,"position":3,"is_corresponding":false},{"id":282836,"name":"Qi Qi","orcid":"0000-0001-8496-5472","position":4,"is_corresponding":false},{"id":1515735,"name":"Jianmin Luo","orcid":null,"position":5,"is_corresponding":false},{"id":687020,"name":"Kun Wang","orcid":"0000-0003-3414-2552","position":6,"is_corresponding":false},{"id":906960,"name":"Zhiqiang Meng","orcid":"0000-0002-1947-1609","position":7,"is_corresponding":false},{"id":443088,"name":"Zhen Chen","orcid":"0000-0002-5590-3552","position":8,"is_corresponding":false},{"id":1272069,"name":"Peng Wang","orcid":"0000-0002-5699-3676","position":9,"is_corresponding":false},{"id":1515736,"name":"Luming Liu","orcid":null,"position":10,"is_corresponding":false},{"id":1184292,"name":"Lianyu Chen","orcid":"0000-0003-3731-8592","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chinese Herbal Medicine Suppresses Invasion-Promoting Capacity of Cancer-Associated Fibroblasts in Pancreatic Cancer","abstract":"Pancreatic cancer remains one of the leading causes of cancer-related deaths, due to aggressive growth, high metastatic rates during the early stage and the lack of an effective therapeutic approach. We previously showed that Qingyihuaji (QYHJ), a seven-herb Chinese medicine formula, exhibited significant anti-cancer effects in pancreatic cancer, associated with modifications in the tumor microenvironment, particularly the inhibition of cancer-associated fibroblast (CAF) activation. In the present study, we generated CAF and paired normal fibroblast (NF) cultures from resected human pancreatic cancer tissues. We observed that CAFs exhibited an enhanced capacity for inducing pancreatic cancer cell migration and invasion compared with NFs, while QYHJ-treated CAFs exhibited decreased migration and invasion-promoting capacities in vitro. The results of further analyses indicated that compared with NFs, CAFs exhibit increased CXCL1, 2 and 8 expression, contributing to the enhanced invasion-promoting capacities of these cells, while QYHJ treatment significantly suppressed CAF proliferation activities and the production of CAF-derived CXCL1, 2 and 8. These in vitro observations were confirmed in mice models of human pancreatic cancer. Taken together, these results suggested that suppressing the tumor-promoting capacity of CAFs through Chinese herbal medicine attenuates pancreatic cancer cell invasion.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24781445","pmcid":"PMC4004556","openalex_id":"https://openalex.org/W1969999498","authors":[],"funders":[],"total_grants":0,"fwci":1.2428,"citation_percentile":0.78759824,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096177&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096177&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0096177","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0096177","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24781445","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.801.1882","host_type":""},{"url":"https://doaj.org/article/20ec8b48022f41f99b11b89e7362fb0a","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC4004556","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_Chinese_Herbal_Medicine_Suppresses_Invasion_Promoting_Capacity_of_Cancer_Associated_Fibroblasts_in_Pancreatic_Cancer_/1009496","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4004556","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4004556","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4004556?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer Cells and Metastasis","Pancreatic and Hepatic Oncology Research","Cancer, Stress, Anesthesia, and Immune Response","Animals","Antineoplastic Agents, Phytogenic","Cell Line, Tumor","Cell Movement","Cell Proliferation","Chemokines, CXC","Drugs, Chinese Herbal","Female","Fibroblasts","Humans","Mice","Mice, Inbred BALB C","Neoplasm Invasiveness","Pancreas","Pancreatic Neoplasms","Tumor Cells, Cultured"],"mesh_terms":["Animals","Antineoplastic Agents, Phytogenic","Cell Movement","Drugs, Chinese Herbal","Female","Fibroblasts","Humans","Mice, Inbred BALB C","Neoplasm Invasiveness","Pancreas","Pancreatic Neoplasms","Tumor Cells, Cultured","Chemokines, CXC","Cell Line, Tumor","Cell Proliferation","Mice"],"keywords":["Pancreatic cancer","Cancer-Associated Fibroblasts","Cancer research","Cancer","Cancer cell","Medicine","CXCL1","Tumor microenvironment","Fibroblast","In vitro","Biology","Internal medicine","Inflammation","Biochemistry","Chemokine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T20:58:40.110805Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}