{"doi":"10.1371/journal.pone.0082225","title":"A New Model to Estimate Prognosis in Patients with Hepatocellular Carcinoma after Yttrium-90 Radioembolization","abstract":null,"journal":"PLoS ONE","year":2013,"id":671904,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1755405,"name":"Judith Ertle","orcid":null,"position":1,"is_corresponding":false},{"id":1755406,"name":"Shaoping Zheng","orcid":null,"position":2,"is_corresponding":false},{"id":1755407,"name":"Thomas Lauenstein","orcid":null,"position":3,"is_corresponding":false},{"id":1755408,"name":"Stefan Mueller","orcid":null,"position":4,"is_corresponding":false},{"id":1755409,"name":"Andreas Bockisch","orcid":null,"position":5,"is_corresponding":false},{"id":1755410,"name":"Guido Gerken","orcid":null,"position":6,"is_corresponding":false},{"id":1609133,"name":"Dongliang Yang","orcid":"0000-0002-8605-6720","position":7,"is_corresponding":false},{"id":1755411,"name":"Joerg F. Schlaak","orcid":null,"position":8,"is_corresponding":false},{"id":1755404,"name":"Zhihong Weng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A New Model to Estimate Prognosis in Patients with Hepatocellular Carcinoma after Yttrium-90 Radioembolization","abstract":"AIMS: The current prognostic model to estimate the survival in hepatocellular carcinoma (HCC) patients treated with transarterial hepatic selective internal radiotherapy (SIRT) is not fully characterized. The aim of this study was to establish a new scoring model including assessment of both tumor responses and therapy-induced systemic changes in HCC patients to predict survival at an early time point post-SIRT. METHODS AND MATERIALS: Between 2008 and 2012, 149 HCC patients treated with SIRT were included into this study. CT images and biomarkers in blood tested at one month post-SIRT were analyzed and correlated with clinical outcome. Tumor responses were assessed by RECIST 1.1, mRECIST, and Choi criteria. Kaplan-Meier methods were used to estimate survival curves. Cox regression was used in uni- and multivariable survival analyses and in the establishment of a prognostic model. RESULTS: A multivariate proportional hazards model was created based on the tumor response, the number of tumor nodules, the score of the model for end stage liver disease (MELD), and the serum C-reactive protein levels which were independent predictors of survival in HCC patients at one month post-SIRT. This prognostic model accurately differentiated the outcome of patients with different risk scores in this cohort (P<0.001). The model also had the ability to assign a predicted survival probability for individual patients. CONCLUSIONS: A new model to predict survival of HCC patients mainly based on tumor responses and therapy-induced systemic changes provides reliable prognosis and accurately discriminates the survival at an early time point after SIRT in these patients.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24367506","pmcid":"PMC3867327","openalex_id":"https://openalex.org/W2050197467","authors":[],"funders":[],"total_grants":0,"fwci":1.427,"citation_percentile":0.81325217,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082225&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082225&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0082225","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0082225","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24367506","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3867327","host_type":"repository"},{"url":"https://doaj.org/article/0ea988f7ebbb4ce0bcb6e2cdd87f4cd5","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3867327","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3867327?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Hepatocellular Carcinoma Treatment and Prognosis","Cholangiocarcinoma and Gallbladder Cancer Studies","Pancreatic and Hepatic Oncology Research","Adolescent","Adult","Aged","Aged, 80 and over","Carcinoma, Hepatocellular","End Stage Liver Disease","Female","Humans","Kaplan-Meier Estimate","Liver Neoplasms","Male","Middle Aged","Proportional Hazards Models","Radiography","Young Adult","Yttrium"],"mesh_terms":["Adolescent","Adult","Aged","Aged, 80 and over","Female","Carcinoma, Hepatocellular","Humans","Liver Neoplasms","Male","Middle Aged","Radiography","Yttrium","Proportional Hazards Models","Kaplan-Meier Estimate","Young Adult","End Stage Liver Disease"],"keywords":["Hepatocellular carcinoma","Medicine","Proportional hazards model","Selective internal radiation therapy","Internal medicine","Oncology","Survival analysis","Stage (stratigraphy)","Prognostic model","Cohort","Response Evaluation Criteria in Solid Tumors","Multivariate analysis","Radiation therapy","Overall survival","Disease","Progressive disease","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T05:13:45.283817Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}