{"doi":"10.1371/journal.pone.0074666","title":"Nkd1 Functions as a Passive Antagonist of Wnt Signaling","abstract":null,"journal":"PLoS ONE","year":2013,"id":589387,"datarank":2.0591199297901093,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":1.4815977895336003,"self_endowment_contribution":0.5775221402565088,"citer_contribution":1.4815977895336003,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":43,"citers_with_citation_signal":35,"citers_with_endowment":35,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1507975,"name":"Terence J. Van Raay","orcid":null,"position":1,"is_corresponding":false},{"id":1507974,"name":"Diane Angonin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nkd1 Functions as a Passive Antagonist of Wnt Signaling","abstract":"Wnt signaling is involved in many aspects of development and in the homeostasis of stem cells. Its importance is underscored by the fact that misregulation of Wnt signaling has been implicated in numerous diseases, especially colorectal cancer. However, how Wnt signaling regulates itself is not well understood. There are several Wnt negative feedback regulators, which are active antagonists of Wnt signaling, but one feedback regulator, Nkd1, has reduced activity compared to other antagonists, yet is still a negative feedback regulator. Here we describe our efforts to understand the role of Nkd1 using Wnt signaling compromised zebrafish mutant lines. In several of these lines, Nkd1 function was not any more active than it was in wild type embryos. However, we found that Nkd1's ability to antagonize canonical Wnt/β-catenin signaling was enhanced in the Wnt/Planar Cell Polarity mutants silberblick (slb/wnt11) and trilobite (tri/vangl2). While slb and tri mutants do not display alterations in canonical Wnt signaling, we found that they are hypersensitive to it. Overexpression of the canonical Wnt/β-catenin ligand Wnt8a in slb or tri mutants resulted in dorsalized embryos, with tri mutants being much more sensitive to Wnt8a than slb mutants. Furthermore, the hyperdorsalization caused by Wnt8a in tri could be rescued by Nkd1. These results suggest that Nkd1 functions as a passive antagonist of Wnt signaling, functioning only when homeostatic levels of Wnt signaling have been breached or when Wnt signaling becomes destabilized.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24009776","pmcid":"PMC3756965","openalex_id":"https://openalex.org/W2013913094","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":1.2382,"citation_percentile":0.78069511,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":4},{"year":2016,"count":3},{"year":2017,"count":6},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":5},{"year":2021,"count":4},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":6},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074666&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074666&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0074666","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0074666","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24009776","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.775.344","host_type":""},{"url":"https://doaj.org/article/d563156882944c578ad7c1da60cec04d","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3756965","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3756965","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3756965","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3756965?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0074666","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0074666","host_type":""}],"fields_of_study":["Wnt/β-catenin signaling in development and cancer","Cancer-related gene regulation","0301 basic medicine","03 medical and health sciences","Animals","Body Patterning","Carrier Proteins","Cytoskeletal Proteins","Embryonic Development","Gene Expression Regulation, Developmental","Membrane Proteins","Mutation","Wnt Proteins","Wnt Signaling Pathway","Zebrafish","Zebrafish Proteins","beta Catenin"],"mesh_terms":["Animals","Carrier Proteins","Cytoskeletal Proteins","Membrane Proteins","Mutation","Zebrafish","Gene Expression Regulation, Developmental","Body Patterning","Zebrafish Proteins","Embryonic Development","Wnt Proteins","beta Catenin","Wnt Signaling Pathway"],"keywords":["Wnt signaling pathway","Mutant","LRP5","LRP6","Beta-catenin","Cell biology","Regulator","Zebrafish","Signal transduction","Chemistry","Biology","Genetics","Gene","Science","Q","R","Embryonic Development","Gene Expression Regulation, Developmental","Membrane Proteins","Zebrafish Proteins","Wnt Proteins","Cytoskeletal Proteins","Mutation","Medicine","Animals","Carrier Proteins","beta Catenin","Research Article","Body Patterning"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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