{"doi":"10.1371/journal.pone.0074351","title":"Alternative Treatments for Indoor Residual Spraying for Malaria Control in a Village with Pyrethroid- and DDT-Resistant Vectors in The Gambia","abstract":null,"journal":"PLoS ONE","year":2013,"id":612670,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1577633,"name":"Majidah Adiamoh","orcid":null,"position":1,"is_corresponding":false},{"id":316972,"name":"Umberto D’Alessandro","orcid":"0000-0001-6341-5009","position":2,"is_corresponding":false},{"id":1577634,"name":"Lamin Jarju","orcid":null,"position":3,"is_corresponding":false},{"id":551156,"name":"Musa Jawara","orcid":null,"position":4,"is_corresponding":false},{"id":1577635,"name":"David Jeffries","orcid":null,"position":5,"is_corresponding":false},{"id":1577636,"name":"Naiela Malik","orcid":null,"position":6,"is_corresponding":false},{"id":488023,"name":"Davis Nwakanma","orcid":"0000-0002-6706-6069","position":7,"is_corresponding":false},{"id":1577637,"name":"Harparkash Kaur","orcid":null,"position":8,"is_corresponding":false},{"id":444296,"name":"Willem Takken","orcid":"0000-0002-1976-0726","position":9,"is_corresponding":false},{"id":344926,"name":"Steve W. Lindsay","orcid":"0000-0002-3461-9050","position":10,"is_corresponding":false},{"id":1577638,"name":"Margaret Pinder","orcid":null,"position":11,"is_corresponding":false},{"id":1378327,"name":"Julie-Anne A. Tangena","orcid":"0000-0002-8188-4498","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Alternative Treatments for Indoor Residual Spraying for Malaria Control in a Village with Pyrethroid- and DDT-Resistant Vectors in The Gambia","abstract":"BACKGROUND: Malaria vector control is threatened by resistance to pyrethroids, the only class of insecticides used for treating bed nets. The second major vector control method is indoor residual spraying with pyrethroids or the organochloride DDT. However, resistance to pyrethroids frequently confers resistance to DDT. Therefore, alternative insecticides are urgently needed. METHODOLOGY/PRINCIPAL FINDINGS: Insecticide resistance and the efficacy of indoor residual spraying with different insecticides was determined in a Gambian village. Resistance of local vectors to pyrethroids and DDT was high (31% and 46% mortality, respectively) while resistance to bendiocarb and pirimiphos methyl was low (88% and 100% mortality, respectively). The vectors were predominantly Anopheles gambiae s.s. with 94% of them having the putative resistant genotype kdr 1014F. Four groups of eight residential compounds were each sprayed with either (1) bendiocarb, a carbamate, (2) DDT, an organochlorine, (3) microencapsulated pirimiphos methyl, an organophosphate, or (4) left unsprayed. All insecticides tested showed high residual activity up to five months after application. Mosquito house entry, estimated by light traps, was similar in all houses with metal roofs, but was significantly less in IRS houses with thatched roofs (p=0.02). Residents participating in focus group discussions indicated that IRS was considered a necessary nuisance and also may decrease the use of long-lasting insecticidal nets. CONCLUSION/SIGNIFICANCE: Bendiocarb and microencapsulated pirimiphos methyl are viable alternatives for indoor residual spraying where resistance to pyrethroids and DDT is high and may assist in the management of pyrethroid resistance.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24058551","pmcid":"PMC3772946","openalex_id":"https://openalex.org/W1994108690","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_UP_A900_1119","title":null},{"funder_name":"Medical Research Council","grant_id":"GO900220","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_UP_A900_1117","title":null},{"funder_name":"Medical Research Council","grant_id":"G0900220","title":null}],"total_grants":4,"fwci":4.7899,"citation_percentile":0.94509933,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":4},{"year":2016,"count":7},{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2022,"count":6},{"year":2023,"count":4},{"year":2024,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074351&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074351&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0074351","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0074351","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24058551","host_type":"repository"},{"url":"http://dro.dur.ac.uk/12442/","host_type":"repository"},{"url":"https://research.wur.nl/en/publications/alternative-treatments-for-indoor-residual-spraying-for-malaria-c","host_type":"journal"},{"url":"https://researchonline.lshtm.ac.uk/view/creators/eideudal.html>;","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.808.3935","host_type":""},{"url":"https://doaj.org/article/cd3dd1c5f9c649f389308e430e32972c","host_type":"repository"},{"url":"https://durham-repository.worktribe.com/output/1465628","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3772946","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_Alternative_Treatments_for_Indoor_Residual_Spraying_for_Malaria_Control_in_a_Village_with_Pyrethroid_and_DDT_Resistant_Vectors_in_The_Gambia_/799044","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3772946","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3772946","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3772946?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Malaria Research and Control","Insect Pest Control Strategies","Pesticide Exposure and Toxicity","Animals","Anopheles","DDT","Female","Focus Groups","Gambia","Genotype","Insect Vectors","Insecticide Resistance","Malaria","Mosquito Control","Pyrethrins","Rural Population"],"mesh_terms":["Animals","Anopheles","DDT","Female","Gambia","Genotype","Insect Vectors","Insecticide Resistance","Malaria","Mosquito Control","Pyrethrins","Rural Population","Focus Groups"],"keywords":["Bendiocarb","Indoor residual spraying","Pyrethroid","Toxicology","Mosquito control","Permethrin","Biology","Carbamate","Organophosphate","Malaria","Pesticide","Veterinary medicine","Biotechnology","Plasmodium falciparum","Agronomy","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.21582709.v1","title":"Additional file 1 of Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.21582709","title":"Additional file 1 of Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25010393.v1","title":"Additional file 1 of Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25010393","title":"Additional file 1 of Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T04:30:32.768481Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}