{"doi":"10.1371/journal.pone.0070005","title":"Analysis of Adaptation Mutants in the Hemagglutinin of the Influenza A(H1N1)pdm09 Virus","abstract":null,"journal":"PLoS ONE","year":2013,"id":596868,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528800,"name":"Esmeralda Alvarado-Facundo","orcid":null,"position":1,"is_corresponding":false},{"id":1528802,"name":"Rosa María Ribas-Aparicio","orcid":null,"position":2,"is_corresponding":false},{"id":1528804,"name":"Juan A. Castelán-Vega","orcid":null,"position":3,"is_corresponding":false},{"id":288454,"name":"Alicia Jiménez-Alberto","orcid":"0000-0002-7127-0791","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of Adaptation Mutants in the Hemagglutinin of the Influenza A(H1N1)pdm09 Virus","abstract":"Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events. The influenza pandemic of 2009 provided a unique scenario to study virus evolution. We performed molecular dynamics simulations with four hemagglutinin variants that appeared throughout the 2009 influenza A (H1N1) pandemic. We found that variant 1 (S143G, S185T) likely arose to avoid immune recognition. Variant 2 (A134T), and variant 3 (D222E, P297S) had an increased binding affinity for the receptor. Finally, variant 4 (E374K) altered hemagglutinin stability in the vicinity of the fusion peptide. Variants 1 and 4 have become increasingly predominant, while variants 2 and 3 declined as the pandemic progressed. Our results show some of the different strategies that the influenza virus uses to adapt to the human host and provide an example of how selective pressure drives antigenic drift in viral proteins.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23894575","pmcid":"PMC3720954","openalex_id":"https://openalex.org/W2014346706","authors":[],"funders":[],"total_grants":0,"fwci":1.5491,"citation_percentile":0.82402367,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070005&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070005&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0070005","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0070005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23894575","host_type":"repository"},{"url":"https://doaj.org/article/dddc816bc7f0446c91f14a30790f59e0","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3720954","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_Analysis_of_Adaptation_Mutants_in_the_Hemagglutinin_of_the_Influenza_A_H1N1_pdm09_Virus_/752157","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3720954","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3720954?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Influenza Virus Research Studies","Protein Structure and Dynamics","RNA and protein synthesis mechanisms","Adaptation, Physiological","Hemagglutinin Glycoproteins, Influenza Virus","Humans","Influenza A Virus, H1N1 Subtype","Influenza Pandemic, 1918-1919","Influenza, Human","Molecular Dynamics Simulation","Molecular Epidemiology","Static Electricity","Surface Properties","Thermodynamics"],"mesh_terms":["Adaptation, Physiological","Humans","Influenza, Human","Surface Properties","Thermodynamics","Molecular Epidemiology","Hemagglutinin Glycoproteins, Influenza Virus","Influenza A Virus, H1N1 Subtype","Static Electricity","Molecular Dynamics Simulation","Influenza Pandemic, 1918-1919"],"keywords":["Hemagglutinin (influenza)","Antigenic drift","Virology","Virus","H5N1 genetic structure","Glycoprotein","Biology","Pandemic","Antigenic shift","Influenza A virus","Mutant","Gene","Coronavirus disease 2019 (COVID-19)","Genetics","Medicine","Infectious disease (medical specialty)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:33:34.562581Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}