{"doi":"10.1371/journal.pone.0060391","title":"CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival","abstract":null,"journal":"PLoS ONE","year":2013,"id":641305,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1667267,"name":"Takuya Ueno","orcid":null,"position":1,"is_corresponding":false},{"id":1667268,"name":"Michael Clarkson","orcid":null,"position":2,"is_corresponding":false},{"id":276440,"name":"Baogong Zhu","orcid":null,"position":3,"is_corresponding":false},{"id":1667269,"name":"Andrea Vergani","orcid":null,"position":4,"is_corresponding":false},{"id":4539,"name":"Gordon J. Freeman","orcid":"0000-0002-7210-5616","position":5,"is_corresponding":false},{"id":1667270,"name":"Mohamed H. Sayegh","orcid":null,"position":6,"is_corresponding":false},{"id":1667271,"name":"Mohammed Javeed I. Ansari","orcid":null,"position":7,"is_corresponding":false},{"id":471860,"name":"Paolo Fiorina","orcid":"0000-0002-1093-7724","position":8,"is_corresponding":false},{"id":1667272,"name":"Antje Habicht","orcid":null,"position":9,"is_corresponding":false},{"id":720706,"name":"Francesca D’Addio","orcid":"0000-0002-0345-0694","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival","abstract":"CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and cytotoxic effector functions. The role of CD160 in alloimmunity is unknown. Using a newly generated CD160 fusion protein (CD160Ig) we examined the role of the novel costimulatory molecule CD160 in mediating CD4(+) or CD8(+) T cell driven allograft rejection. CD160Ig inhibits alloreactive CD8(+) T cell proliferation and IFN-γ production in vitro, in particular in the absence of CD28 costimulation. Consequently CD160Ig prolongs fully mismatched cardiac allograft survival in CD4(-/-), CD28(-/-) knockout and CTLA4Ig treated WT recipients, but not in WT or CD8(-/-) knockout recipients. The prolonged cardiac allograft survival is associated with reduced alloreactive CD8(+) T cell proliferation, effector/memory responses and alloreactive IFN-γ production. Thus, CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23593209","pmcid":"PMC3617215","openalex_id":"https://openalex.org/W2140041178","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"K08 AI080836","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"K08 AI080836-01","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI1051559","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI56299","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI056299","title":null},{"funder_name":"National Institutes of Health","grant_id":"1K08AI080836-01","title":"Role of Novel Th17 cells in allograft rejection and tolerance"}],"total_grants":6,"fwci":1.3482,"citation_percentile":0.80132468,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":5},{"year":2023,"count":1},{"year":2024,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0060391&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0060391&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0060391","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0060391","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23593209","host_type":"repository"},{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:11365693","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.657.4657","host_type":""},{"url":"http://hdl.handle.net/2434/486694","host_type":"repository"},{"url":"https://doaj.org/article/ba81b9c1e01442a696ba4c636420c149","host_type":"repository"},{"url":"https://epub.ub.uni-muenchen.de/15646/","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3617215","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_CD160Ig_Fusion_Protein_Targets_a_Novel_Costimulatory_Pathway_and_Prolongs_Allograft_Survival_/675582","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3617215","host_type":"repository"},{"url":"https://doi.org/10.5282/ubm/epub.15646","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3617215","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3617215?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.5282/ubm/epub.15646","host_type":""},{"url":"http://dx.doi.org/10.1371/journal.pone.0060391","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0060391","host_type":""},{"url":"https://doi.org/https://doi.org/10.1371/journal.pone.0060391","host_type":""}],"fields_of_study":["Immune Cell Function and Interaction","T-cell and B-cell Immunology","Neuropeptides and Animal Physiology","03 medical and health sciences","0302 clinical medicine","Animals","Antigen-Presenting Cells","Antigens, CD","CD28 Antigens","CD4 Antigens","Cytokines","Cytotoxicity, Immunologic","GPI-Linked Proteins","Gene Expression","Graft Survival","Heart Transplantation","Histocompatibility Antigens Class I","Immunoglobulin G","Immunologic Memory","Interferon-gamma","Killer Cells, Natural","Lymphocyte Activation","Mice","Mice, Inbred BALB C","Mice, Inbred C57BL","Mice, Knockout","Receptors, Immunologic","Recombinant Fusion Proteins","Signal Transduction","Skin Transplantation","T-Lymphocyte Subsets","Transplantation, Homologous"],"mesh_terms":["Animals","Antigen-Presenting Cells","Cytotoxicity, Immunologic","Graft Survival","Immunoglobulin G","Immunologic Memory","Interferon-gamma","Killer Cells, Natural","Lymphocyte Activation","Mice, Inbred BALB C","Mice, Inbred C57BL","Receptors, Immunologic","Recombinant Fusion Proteins","Transplantation, Homologous","Histocompatibility Antigens Class I","Signal Transduction","Antigens, CD","CD4 Antigens","Gene Expression","Heart Transplantation","Skin Transplantation","T-Lymphocyte Subsets","Cytokines","CD28 Antigens","Mice, Knockout","Mice","GPI-Linked Proteins"],"keywords":["Cytotoxic T cell","CD28","Alloimmunity","CD8","T cell","Effector","MHC class I","Immunology","Cell biology","Biology","Major histocompatibility complex","Antigen","Immune system","In vitro","Cytotoxicity, Immunologic","Immune Cells","Science","Antigen-Presenting Cells","Gene Expression","610","Antigen Processing and Recognition","GPI-Linked Proteins","Lymphocyte Activation","Immune Activation","Interferon-gamma","Mice","CD28 Antigens","Antigens, CD","Animals","Immunoassays","Immune Response","Transplantation","Mice, Inbred BALB C","T Cells","Q","Graft Survival","Histocompatibility Antigens Class I","Immunity","R","Immunologic Subspecialties","Killer 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