{"doi":"10.1371/journal.pone.0054541","title":"Simultaneous Measurement of Amyloid Fibril Formation by Dynamic Light Scattering and Fluorescence Reveals Complex Aggregation Kinetics","abstract":null,"journal":"PLoS ONE","year":2013,"id":647889,"datarank":3.3253597662906555,"base_score":4.543294782270004,"endowment":4.543294782270004,"self_citation_contribution":0.6814942173405006,"citation_network_contribution":2.643865548950155,"self_endowment_contribution":0.6814942173405006,"citer_contribution":2.643865548950155,"corpus_percentile":null,"corpus_rank":null,"citation_count":93,"citer_count":92,"citers_with_citation_signal":77,"citers_with_endowment":77,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1688149,"name":"Yannick Sourigues","orcid":null,"position":1,"is_corresponding":false},{"id":467783,"name":"Ron R. 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These pathologies are all related by the propensity of their associated protein or polypeptide to form insoluble, β-sheet rich, amyloid fibrils. Despite the wide range of amino acid sequence in the aggregation prone polypeptides associated with these diseases, the resulting amyloids display strikingly similar physical structure, an observation which suggests a physical basis for amyloid fibril formation. Thioflavin T fluorescence reports β-sheet fibril content while dynamic light scattering measures particle size distributions. The combined techniques allow elucidation of complex aggregation kinetics and are used to reveal multiple stages of amyloid fibril formation.","is_dataset_classified":null,"base_score":4.543294782270004,"endowment":4.543294782270004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23349924","pmcid":"PMC3547910","openalex_id":"https://openalex.org/W2067821383","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS042842","title":null}],"total_grants":1,"fwci":2.3354,"citation_percentile":0.87882659,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":5},{"year":2016,"count":8},{"year":2017,"count":4},{"year":2018,"count":9},{"year":2019,"count":5},{"year":2020,"count":7},{"year":2021,"count":13},{"year":2022,"count":10},{"year":2023,"count":6},{"year":2024,"count":9},{"year":2025,"count":6},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054541&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054541&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0054541","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0054541","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23349924","host_type":"repository"},{"url":"https://hal.science/hal-01183062","host_type":"repository"},{"url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054541","host_type":"repository"},{"url":"https://doaj.org/article/adc6b5f3a9714d63bb81864ae90856cc","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3547910","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/Simultaneous_Measurement_of_Amyloid_Fibril_Formation_by_Dynamic_Light_Scattering_and_Fluorescence_Reveals_Complex_Aggregation_Kinetics__/114441","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3547910","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3547910?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Genetic Neurodegenerative Diseases","Prion Diseases and Protein Misfolding","Mitochondrial Function and Pathology","Alzheimer Disease","Amino Acid Sequence","Amyloid","Amyloid beta-Peptides","Benzothiazoles","Fluorescence","Humans","Huntington Disease","Kinetics","Light","Parkinson Disease","Particle Size","Protein Structure, Secondary","Thiazoles"],"mesh_terms":["Alzheimer Disease","Amino Acid Sequence","Amyloid","Fluorescence","Humans","Huntington Disease","Kinetics","Light","Parkinson Disease","Particle Size","Thiazoles","Amyloid beta-Peptides","Protein Structure, Secondary","Benzothiazoles"],"keywords":["Thioflavin","Fibril","Biophysics","Amyloid (mycology)","Kinetics","Dynamic light scattering","Fluorescence","Chemistry","Protein aggregation","Amyloid fibril","Biochemistry","Biology","Alzheimer's disease","Materials science","Amyloid β","Medicine","Nanotechnology","Pathology","Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T01:59:57.900202Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}