{"doi":"10.1371/journal.pone.0052135","title":"Enhancement of the Immunogenicity and Protective Efficacy of a Mucosal Influenza Subunit Vaccine by the Saponin Adjuvant GPI-0100","abstract":null,"journal":"PLoS ONE","year":2012,"id":610067,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1568351,"name":"Harshad P. Patil","orcid":null,"position":1,"is_corresponding":false},{"id":1568352,"name":"Jacqueline de Vries-Idema","orcid":null,"position":2,"is_corresponding":false},{"id":1568353,"name":"Jan Wilschut","orcid":null,"position":3,"is_corresponding":false},{"id":482446,"name":"Anke Huckriede","orcid":"0000-0002-2646-5143","position":4,"is_corresponding":false},{"id":314612,"name":"Heng Liu","orcid":"0000-0001-6683-1462","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Enhancement of the Immunogenicity and Protective Efficacy of a Mucosal Influenza Subunit Vaccine by the Saponin Adjuvant GPI-0100","abstract":"Identification of safe and effective adjuvants remains an urgent need for the development of inactivated influenza vaccines for mucosal administration. Here, we used a murine challenge model to evaluate the adjuvant activity of GPI-0100, a saponin-derived adjuvant, on influenza subunit vaccine administered via the intranasal or the intrapulmonary route. Balb/c mice were immunized with 1 µg A/PR/8 (H1N1) subunit antigen alone or in combination with varying doses of GPI-0100. The addition of GPI-0100 was required for induction of mucosal and systemic antibody responses to intranasally administered influenza vaccine and significantly enhanced the immunogenicity of vaccine administered via the intrapulmonary route. Remarkably, GPI-0100-adjuvanted influenza vaccine given at a low dose of 2×1 µg either in the nares or directly into the lungs provided complete protection against homologous influenza virus infection.","is_dataset_classified":null,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23284901","pmcid":"PMC3524133","openalex_id":"https://openalex.org/W2081589055","authors":[],"funders":[],"total_grants":0,"fwci":1.553,"citation_percentile":0.82332142,"influential_citations":1,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":7},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052135&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052135&type=printable","host_type":"GOLD"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052135&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0052135","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0052135","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23284901","host_type":"repository"},{"url":"https://research.rug.nl/en/publications/f9b34459-54a5-4143-b320-88805985d201","host_type":"repository"},{"url":"https://doaj.org/article/8be410ba3c374d119740365cbdbf4003","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3524133","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3524133","host_type":"repository"},{"url":"https://hdl.handle.net/11370/f9b34459-54a5-4143-b320-88805985d201","host_type":"repository"},{"url":"https://pure.rug.nl/ws/files/48885894/Liu_2012_Enhancement_of_the_immunogenicity_a.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3524133","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3524133?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Influenza Virus Research Studies","Immune Response and Inflammation","Immune Cell Function and Interaction","Biology","Medicine","Adjuvants, Immunologic","Administration, Intranasal","Animals","Antibodies, Viral","Female","Immunoglobulin A, Secretory","Immunoglobulin G","Influenza A Virus, H1N1 Subtype","Influenza Vaccines","Lung","Mice","Mucous Membrane","Orthomyxoviridae Infections","Saponins","T-Lymphocytes, Helper-Inducer","Vaccines, Subunit"],"mesh_terms":["Adjuvants, Immunologic","Administration, Intranasal","Animals","Antibodies, Viral","Female","T-Lymphocytes, Helper-Inducer","Immunoglobulin A, Secretory","Immunoglobulin G","Influenza Vaccines","Lung","Mucous Membrane","Orthomyxoviridae Infections","Saponins","Vaccines, Subunit","Mice","Influenza A Virus, H1N1 Subtype"],"keywords":["Immunogenicity","Adjuvant","Nasal administration","Influenza vaccine","Virology","Saponin","Medicine","Immunology","Influenza A virus","Antigen","Virus","Microbiology","Biology","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T19:03:21.589857Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}