{"doi":"10.1371/journal.pone.0043155","title":"Characterization of the Rat Oncostatin M Receptor Complex Which Resembles the Human, but Differs from the Murine Cytokine Receptor","abstract":null,"journal":"PLoS ONE","year":2012,"id":636058,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":740535,"name":"Joachim Grötzinger","orcid":null,"position":1,"is_corresponding":false},{"id":1650505,"name":"Heike M. Hermanns","orcid":null,"position":2,"is_corresponding":false},{"id":1650503,"name":"Johannes Drechsler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Characterization of the Rat Oncostatin M Receptor Complex Which Resembles the Human, but Differs from the Murine Cytokine Receptor","abstract":"Evaluation of a pathophysiological role of the interleukin-6-type cytokine oncostatin M (OSM) for human diseases has been complicated by the fact that mouse models of diseases targeting either OSM or the OSM receptor (OSMR) complex cannot fully reflect the human situation. This is due to earlier findings that human OSM utilizes two receptor complexes, glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR) (type I) and gp130/OSMR (type II), both with wide expression profiles. Murine OSM on the other hand only binds to the gp130/OSMR (type II) receptor complex with high affinity. Here, we characterize the receptor usage for rat OSM. Using different experimental approaches (knock-down of the OSMR expression by RNA interference, blocking of the LIFR by LIF-05, an antagonistic LIF variant and stably transfected Ba/F3 cells) we can clearly show that rat OSM surprisingly utilizes both, the type I and type II receptor complex, therefore mimicking the human situation. Furthermore, it displays cross-species activities and stimulates cells of human as well as murine origin. Its signaling capacities closely mimic those of human OSM in cell types of different origin in the way that strong activation of the Jak/STAT, the MAP kinase as well as the PI3K/Akt pathways can be observed. Therefore, rat disease models would allow evaluation of the relevance of OSM for human biology.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22937020","pmcid":"PMC3425591","openalex_id":"https://openalex.org/W2122940233","authors":[],"funders":[],"total_grants":0,"fwci":0.9583,"citation_percentile":0.75490904,"influential_citations":2,"citation_trend":[{"year":2013,"count":4},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":9},{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043155&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043155&type=printable","host_type":"GOLD"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043155&type=printable","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0043155","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22937020","host_type":"repository"},{"url":"https://doaj.org/article/75459aa9411e4a0fa1a6bc4029fd2c93","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3425591","host_type":"repository"},{"url":"https://figshare.com/articles/Characterization_of_the_Rat_Oncostatin_M_Receptor_Complex_Which_Resembles_the_Human_but_Differs_from_the_Murine_Cytokine_Receptor/121003","host_type":"repository"},{"url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/13387","host_type":"repository"},{"url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-78856","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3425591","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3425591?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cytokine Signaling Pathways and Interactions","Chemokine receptors and signaling","interferon and immune responses","Biology","Medicine"],"mesh_terms":["Animals","Cell Line","Cells, Cultured","Humans","Protein Binding","Blotting, Western","Signal Transduction","Receptors, Cytokine","Reverse Transcriptase Polymerase Chain Reaction","RNA, Small Interfering","Cell Proliferation","Mice","Rats","Receptors, Oncostatin M"],"keywords":["Oncostatin M","Leukemia inhibitory factor receptor","Glycoprotein 130","Leukemia inhibitory factor","Receptor","Biology","Cell biology","Cytokine receptor","Interleukin-21 receptor","Common gamma chain","Cytokine","Signal transduction","Interleukin-6 receptor","Molecular biology","Interleukin 6","Immunology","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T16:05:01.553358Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}