{"doi":"10.1371/journal.pone.0040414","title":"Ontogeny of Mouse Vestibulo-Ocular Reflex Following Genetic or Environmental Alteration of Gravity Sensing","abstract":null,"journal":"PLoS ONE","year":2012,"id":613795,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1581425,"name":"Mickael Bojados","orcid":null,"position":1,"is_corresponding":false},{"id":1581426,"name":"Anne Le Séac’h","orcid":null,"position":2,"is_corresponding":false},{"id":1581427,"name":"Marc Jamon","orcid":null,"position":3,"is_corresponding":false},{"id":1581428,"name":"Pierre-Paul Vidal","orcid":null,"position":4,"is_corresponding":false},{"id":743362,"name":"Mathieu Beraneck","orcid":"0000-0003-2722-0532","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ontogeny of Mouse Vestibulo-Ocular Reflex Following Genetic or Environmental Alteration of Gravity Sensing","abstract":"The vestibular organs consist of complementary sensors: the semicircular canals detect rotations while the otoliths detect linear accelerations, including the constant pull of gravity. Several fundamental questions remain on how the vestibular system would develop and/or adapt to prolonged changes in gravity such as during long-term space journey. How do vestibular reflexes develop if the appropriate assembly of otoliths and semi-circular canals is perturbed? The aim of present work was to evaluate the role of gravity sensing during ontogeny of the vestibular system. In otoconia-deficient mice (ied), gravity cannot be sensed and therefore maculo-ocular reflexes (MOR) were absent. While canals-related reflexes were present, the ied deficit also led to the abnormal spatial tuning of the horizontal angular canal-related VOR. To identify putative otolith-related critical periods, normal C57Bl/6J mice were subjected to 2G hypergravity by chronic centrifugation during different periods of development or adulthood (Adult-HG) and compared to non-centrifuged (control) C57Bl/6J mice. Mice exposed to hypergravity during development had completely normal vestibulo-ocular reflexes 6 months after end of centrifugation. Adult-HG mice all displayed major abnormalities in maculo-ocular reflexe one month after return to normal gravity. During the next 5 months, adaptation to normal gravity occurred in half of the individuals. In summary, genetic suppression of gravity sensing indicated that otolith-related signals might be necessary to ensure proper functioning of canal-related vestibular reflexes. On the other hand, exposure to hypergravity during development was not sufficient to modify durably motor behaviour. Hence, 2G centrifugation during development revealed no otolith-specific critical period.","is_dataset_classified":null,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22808156","pmcid":"PMC3393735","openalex_id":"https://openalex.org/W2056619484","authors":[],"funders":[{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-09-BLAN-0148","title":null}],"total_grants":1,"fwci":1.8735,"citation_percentile":0.84541917,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":8},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":5},{"year":2020,"count":6},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":8},{"year":2024,"count":8},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0040414&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0040414&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0040414","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0040414","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22808156","host_type":"repository"},{"url":"https://doaj.org/article/2dd19a481f844d40a2c6ca43f9e78e32","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3393735","host_type":"repository"},{"url":"https://figshare.com/articles/figure/Ontogeny_of_Mouse_Vestibulo_Ocular_Reflex_Following_Genetic_or_Environmental_Alteration_of_Gravity_Sensing/122910","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3393735","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3393735?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0040414","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0040414","host_type":""}],"fields_of_study":["Vestibular and auditory disorders","Ophthalmology and Eye Disorders","Spaceflight effects on biology","0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Aging","Animals","Environment","Mice, Inbred C57BL","Otolithic Membrane","Reflex, Vestibulo-Ocular","Gravity Sensing","Hypergravity","Mice"],"keywords":["Hypergravity","Vestibular system","Reflex","Otolith","Righting reflex","Semicircular canal","Vestibulo–ocular reflex","Medial vestibular nucleus","Anatomy","Biology","Weightlessness","Vestibular nuclei","Medicine","Neuroscience","Physics","Internal medicine","Aging","Science","Q","R","Reflex, Vestibulo-Ocular","Environment","Mice, Inbred C57BL","Mice","Otolithic Membrane","Animals","Gravity Sensing","Research Article"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T09:15:42.130000Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}