{"doi":"10.1371/journal.pone.0027332","title":"Vessel Arterial-Venous Plasticity in Adult Neovascularization","abstract":null,"journal":"PLoS ONE","year":2011,"id":660958,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1182136,"name":"Harish Rekapally","orcid":null,"position":1,"is_corresponding":false},{"id":1725401,"name":"Carlos C. Chang","orcid":null,"position":2,"is_corresponding":false},{"id":390015,"name":"James B. Hoying","orcid":"0000-0001-7959-227X","position":3,"is_corresponding":false},{"id":1443860,"name":"Sara S. Nunes","orcid":"0000-0003-0906-7204","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Vessel Arterial-Venous Plasticity in Adult Neovascularization","abstract":"OBJECTIVE: Proper arterial and venous specification is a hallmark of functional vascular networks. While arterial-venous identity is genetically pre-determined during embryo development, it is unknown whether an analogous pre-specification occurs in adult neovascularization. Our goal is to determine whether vessel arterial-venous specification in adult neovascularization is pre-determined by the identity of the originating vessels. METHODS AND RESULTS: We assessed identity specification during neovascularization by implanting isolated microvessels of arterial identity from both mice and rats and assessing the identity outcomes of the resulting, newly formed vasculature. These microvessels of arterial identity spontaneously formed a stereotypical, perfused microcirculation comprised of the full complement of microvessel types intrinsic to a mature microvasculature. Changes in microvessel identity occurred during sprouting angiogenesis, with neovessels displaying an ambiguous arterial-venous phenotype associated with reduced EphrinB2 phosphorylation. CONCLUSIONS: Our findings indicate that microvessel arterial-venous identity in adult neovascularization is not necessarily pre-determined and that adult microvessels display a considerable level of phenotypic plasticity during neovascularization. In addition, we show that vessels of arterial identity also hold the potential to undergo sprouting angiogenesis.","is_dataset_classified":null,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22132096","pmcid":"PMC3221655","openalex_id":"https://openalex.org/W2020808375","authors":[],"funders":[{"funder_name":"NIBIB NIH HHS","grant_id":"R01 EB007556","title":null},{"funder_name":"NIBIB NIH HHS","grant_id":"EB007556","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01EB007556-03","title":"Fabricated Microvascular Networks"}],"total_grants":3,"fwci":0.851,"citation_percentile":0.70730235,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":2},{"year":2015,"count":8},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":5},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027332&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027332&type=printable","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0027332","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22132096","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221655","host_type":"repository"},{"url":"https://doaj.org/article/59e407f0f741454995f72594dfc8ef45","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3221655","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3221655?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0027332","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0027332","host_type":""}],"fields_of_study":["Angiogenesis and VEGF in Cancer","Axon Guidance and Neuronal Signaling","Barrier Structure and Function Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Aging","Animals","Arteries","Arterioles","Genetic Markers","Microcirculation","Microspheres","Veins","Biomarkers","Neovascularization, Physiologic","Mice","Rats"],"keywords":["Microvessel","Neovascularization","Angiogenesis","Sprouting angiogenesis","Blood vessel","Pathology","Microcirculation","Medicine","Anatomy","Biology","Internal medicine","Genetic Markers","Aging","Science","Q","R","Neovascularization, Physiologic","Arteries","Microspheres","Rats","Veins","Arterioles","Mice","Animals","Biomarkers","Research Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T10:10:51.603659Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}