{"doi":"10.1371/journal.pone.0019475","title":"Enhancement of Neoangiogenesis and Follicle Survival by Sphingosine-1-Phosphate in Human Ovarian Tissue Xenotransplants","abstract":null,"journal":"PLoS ONE","year":2011,"id":603263,"datarank":0.7947476049822055,"base_score":5.298317366548036,"endowment":5.298317366548036,"self_citation_contribution":0.7947476049822055,"citation_network_contribution":0.0,"self_endowment_contribution":0.7947476049822055,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":199,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547518,"name":"Elke Heytens","orcid":null,"position":1,"is_corresponding":false},{"id":305252,"name":"Kutluk Oktay","orcid":"0000-0003-0914-7757","position":2,"is_corresponding":false},{"id":1547517,"name":"Reza Soleimani","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Enhancement of Neoangiogenesis and Follicle Survival by Sphingosine-1-Phosphate in Human Ovarian Tissue Xenotransplants","abstract":"Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization. Here we investigated whether sphingosine-1-phosphate or its receptor agonists could enhance neoangiogenesis and follicle survival in ovarian transplants in a xenograft model. Human ovarian tissue xenografts in severe-combined-immunodeficient mice were treated with sphingosine-1-phosphate, its analogs, or vehicle for 1-10 days. We found that sphingosine-1-phosphate treatment increased vascular density in ovarian transplants significantly whereas FTY720 and SEW2871 had the opposite effect. In addition, sphingosine-1-phosphate accelerated the angiogenic process compared to vehicle-treated controls. Furthermore, sphingosine-1-phosphate treatment was associated with a significant proliferation of ovarian stromal cell as well as reduced necrosis and tissue hypoxia compared to the vehicle-treated controls. This resulted in a significantly lower percentage of apoptotic follicles in sphingosine-1-phosphate-treated transplants. We conclude that while sphingosine-1-phosphate promotes neoangiogenesis in ovarian transplants and reduces ischemic reperfusion injury, sphingosine-1-phosphate receptor agonists appear to functionally antagonize this process. Sphingosine-1-phosphate holds great promise to clinically enhance the survival and longevity of human autologous ovarian transplants.","is_dataset_classified":null,"base_score":5.298317366548036,"endowment":5.298317366548036,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21559342","pmcid":"PMC3084884","openalex_id":"https://openalex.org/W1979917621","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD053112","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R21 HD061259","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"HD053112","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R21HD061259-02","title":"Improving Primordial Follicle Survival After Transplantation of Cryopreserved Hum"}],"total_grants":4,"fwci":3.5278,"citation_percentile":0.93638021,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":12},{"year":2014,"count":11},{"year":2015,"count":22},{"year":2016,"count":10},{"year":2017,"count":13},{"year":2018,"count":15},{"year":2019,"count":13},{"year":2020,"count":16},{"year":2021,"count":20},{"year":2022,"count":17},{"year":2023,"count":16},{"year":2024,"count":16},{"year":2025,"count":11},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019475&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019475&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0019475","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0019475","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21559342","host_type":"repository"},{"url":"https://biblio.ugent.be/publication/6999490","host_type":"repository"},{"url":"https://doaj.org/article/e3a7ffe2b592480995172c1da5cb70ed","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084884","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/Enhancement_of_Neoangiogenesis_and_Follicle_Survival_by_Sphingosine_1_Phosphate_in_Human_Ovarian_Tissue_Xenotransplants/137211","host_type":"repository"},{"url":"https://biblio.ugent.be/publication/6999490/file/6999498.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3084884","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3084884?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0019475","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0019475","host_type":""},{"url":"http://hdl.handle.net/1854/LU-6999490","host_type":""},{"url":"http://doi.org/10.1371/journal.pone.0019475","host_type":""},{"url":"https://biblio.ugent.be/publication/6999490/file/6999498","host_type":""}],"fields_of_study":["Sphingolipid Metabolism and Signaling","Reproductive Biology and Fertility","Ovarian function and disorders","03 medical and health sciences","0302 clinical medicine","Animals","Apoptosis","Cryopreservation","Female","Fingolimod Hydrochloride","Graft Survival","Humans","Immunohistochemistry","Immunosuppressive Agents","Lysophospholipids","Mice","Mice, SCID","Neovascularization, Physiologic","Ovarian Follicle","Ovary","Oxadiazoles","Propylene Glycols","Sphingosine","Thiophenes","Transplantation, Heterologous"],"mesh_terms":["Fingolimod Hydrochloride","Animals","Female","Ovarian Follicle","Graft Survival","Humans","Immunohistochemistry","Immunosuppressive Agents","Lysophospholipids","Ovary","Oxadiazoles","Propylene Glycols","Sphingosine","Thiophenes","Transplantation, Heterologous","Cryopreservation","Mice, SCID","Apoptosis","Neovascularization, Physiologic","Mice"],"keywords":["Sphingosine-1-phosphate","Sphingosine","Sphingosine-1-phosphate receptor","Biology","Endocrinology","Fertility preservation","Transplantation","Internal medicine","S1PR1","Andrology","Medicine","Receptor","Vascular endothelial growth factor","Population","Fertility","Vascular endothelial growth factor A","FTY720","Science","Transplantation, Heterologous","Neovascularization, Physiologic","ISCHEMIA-REPERFUSION INJURY","Apoptosis","Mice, SCID","Thiophenes","ANGIOGENESIS","Mice","SPHINGOSINE 1-PHOSPHATE","Ovarian Follicle","EXTRACELLULAR-MATRIX","Animals","Humans","Cryopreservation","Oxadiazoles","Fingolimod Hydrochloride","Q","Graft Survival","Ovary","R","Biology and Life Sciences","RECEPTOR EDG-1","ENDOTHELIAL-CELLS","Immunohistochemistry","ACTIVIN-A","Propylene Glycols","Female","Lysophospholipids","LYSOPHOSPHATIDIC ACID","Immunosuppressive Agents","Research Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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