{"doi":"10.1371/journal.pone.0018472","title":"Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain","abstract":null,"journal":"PLoS ONE","year":2011,"id":588883,"datarank":9.76785125042989,"base_score":5.60947179518496,"endowment":5.60947179518496,"self_citation_contribution":0.8414207692777441,"citation_network_contribution":8.926430481152146,"self_endowment_contribution":0.8414207692777441,"citer_contribution":8.926430481152146,"corpus_percentile":null,"corpus_rank":null,"citation_count":272,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1235047,"name":"Jessica L. Ables","orcid":"0000-0003-1818-3506","position":1,"is_corresponding":false},{"id":1506665,"name":"Lauren K. Dickel","orcid":null,"position":2,"is_corresponding":false},{"id":258796,"name":"Amelia J. Eisch","orcid":"0000-0001-6476-5385","position":3,"is_corresponding":false},{"id":897655,"name":"Jane E. Johnson","orcid":"0000-0003-3829-8116","position":4,"is_corresponding":false},{"id":267586,"name":"Euiseok J. Kim","orcid":"0000-0002-8271-2209","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain","abstract":"Ascl1 (Mash1) is a bHLH transcription factor essential for neural differentiation during embryogenesis but its role in adult neurogenesis is less clear. Here we show that in the adult brain Ascl1 is dynamically expressed during neurogenesis in the dentate gyrus subgranular zone (SGZ) and more rostral subventricular zone (SVZ). Specifically, we find Ascl1 levels low in SGZ Type-1 cells and SVZ B cells but increasing as the cells transition to intermediate progenitor stages. In vivo genetic lineage tracing with a tamoxifen (TAM) inducible Ascl1CreERT2 knock-in mouse strain shows that Ascl1 lineage cells continuously generate new neurons over extended periods of time. There is a regionally-specific difference in neuron generation, with mice given TAM at postnatal day 50 showing new dentate gyrus neurons through 30 days post-TAM, but showing new olfactory bulb neurons even 180 days post-TAM. These results show that Ascl1 is not restricted to transit amplifying populations but is also found in a subset of neural stem cells with long-term neurogenic potential in the adult brain.","is_dataset_classified":null,"base_score":5.60947179518496,"endowment":5.60947179518496,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21483754","pmcid":"PMC3069117","openalex_id":"https://openalex.org/W2094842746","authors":[],"funders":[{"funder_name":"NIDA NIH HHS","grant_id":"K02 DA023555","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS032817","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R21 DA023701","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS32817","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD037932","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"T32 MH076690","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R01NS032817-08","title":"Regulation and Function of Mash1 in Neural Development"},{"funder_name":"National Institutes of Health","grant_id":"2K02DA023555-06","title":"New Horizons in Adult Neurogenesis"},{"funder_name":"National Institutes of Health","grant_id":"5R21DA023701-02","title":"Cdk5 and adult hippocampal neurogenesis"},{"funder_name":"National Institutes of Health","grant_id":"5T32MH076690-02","title":"Basic Science Training Program in the Neurobiology of Mental Illness"}],"total_grants":10,"fwci":6.6907,"citation_percentile":0.97855194,"influential_citations":0,"citation_trend":[{"year":2012,"count":15},{"year":2013,"count":11},{"year":2014,"count":22},{"year":2015,"count":13},{"year":2016,"count":16},{"year":2017,"count":15},{"year":2018,"count":16},{"year":2019,"count":21},{"year":2020,"count":25},{"year":2021,"count":18},{"year":2022,"count":22},{"year":2023,"count":28},{"year":2024,"count":13},{"year":2025,"count":20},{"year":2026,"count":10}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018472&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018472&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pone.0018472","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pone.0018472","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21483754","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.291.7525","host_type":""},{"url":"https://doaj.org/article/fc6b390e10af40c880c5eb6bc0a58b76","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3069117","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3069117","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3069117?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pone.0018472","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pone.0018472","host_type":""}],"fields_of_study":["Pluripotent Stem Cells Research","Neurogenesis and neuroplasticity mechanisms","Renal and related cancers","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Basic Helix-Loop-Helix Proteins","Brain","Cell Differentiation","Dentate Gyrus","Mice","Neural Stem Cells","Neurogenesis"],"mesh_terms":["Animals","Brain","Cell Differentiation","Dentate Gyrus","Mice","Basic Helix-Loop-Helix Transcription Factors","Basic Helix-Loop-Helix Proteins","Neurogenesis","Neural Stem Cells"],"keywords":["Subgranular zone","Subventricular zone","Neurogenesis","Rostral migratory stream","Dentate gyrus","Biology","Neural stem cell","Olfactory bulb","Neuroscience","Gliogenesis","Fate mapping","Progenitor cell","Cell biology","Stem cell","Hippocampus","Central nervous system","Basic Helix-Loop-Helix Proteins","Science","Q","R","Brain","Cell Differentiation","Mice","Neural Stem Cells","Medicine","Animals","Research Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-22T23:52:30.535116Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}