{"doi":"10.1371/journal.pntd.0012375","title":"Hepatitis E virus in the Kathmandu Valley: Insights from a representative longitudinal serosurvey","abstract":"BACKGROUND: Hepatitis-E virus (HEV), an etiologic agent of acute inflammatory liver disease, is a significant cause of morbidity and mortality in South Asia. HEV is considered endemic in Nepal; but data on population-level infection transmission is sparse. METHODS: We conducted a longitudinal serosurvey in central Nepal to assess HEV exposure. At each visit, capillary blood samples were collected and analyzed for the presence of anti-HEV IgG antibodies. The study took place between February 2019 and April 2021, with up to 4 visits per participant approximately 6 months apart. RESULTS: We collected 2513 samples from 923 participants aged 0-25 years, finding a seroprevalence of 4.8% and a seroincidence rate of 10.9 per 1000 person-years. Young adults and individuals consuming surface water faced the highest incidence of infection. Geospatial analysis identified potential HEV clusters, suggesting a need for targeted interventions. SIGNIFICANCE: Our findings demonstrate that HEV is endemic in Nepal and that the risk of infection increases with age.","journal":"PLoS neglected tropical diseases","year":2024,"id":478980,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8868,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":998803,"name":"Melina Thapa","orcid":null,"position":1,"is_corresponding":false},{"id":860454,"name":"Sony Shrestha","orcid":"0000-0003-1134-6309","position":2,"is_corresponding":false},{"id":861139,"name":"Krista Vaidya","orcid":null,"position":3,"is_corresponding":false},{"id":297725,"name":"Isaac I. Bogoch","orcid":"0000-0003-1590-6748","position":4,"is_corresponding":false},{"id":860451,"name":"Rajeev Shrestha","orcid":"0000-0001-8233-3754","position":5,"is_corresponding":false},{"id":231886,"name":"Jason R. Andrews","orcid":"0000-0002-5967-251X","position":6,"is_corresponding":false},{"id":1317954,"name":"Dipesh Tamrakar","orcid":"0000-0002-7258-1436","position":7,"is_corresponding":false},{"id":392039,"name":"Kristen Aiemjoy","orcid":"0000-0003-1886-2699","position":8,"is_corresponding":false},{"id":860453,"name":"Nishan Katuwal","orcid":"0000-0002-8557-5879","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:06:50.355747Z","pmid":"39102451","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}