{"doi":"10.1371/journal.pntd.0011948","title":"Longitudinal analysis of post-acute chikungunya-associated arthralgia in children and adults: A prospective cohort study in Managua, Nicaragua (2014–2018)","abstract":"Chikungunya can result in debilitating arthralgia, often presenting as acute, self-limited pain, but occasionally manifesting chronically. Little is known about differences in chikungunya-associated arthralgia comparing children to adults over time. To characterize long-term chikungunya-associated arthralgia, we recruited 770 patients (105 0-4 years old [y/o], 200 5-9 y/o, 307 10-15 y/o, and 158 16+ y/o) with symptomatic chikungunya virus infections in Managua, Nicaragua, during two consecutive chikungunya epidemics (2014-2015). Participants were assessed at ~15 days and 1, 3, 6, 12, and 18 months post-fever onset. Following clinical guidelines, we defined participants by their last reported instance of arthralgia as acute (≤10 days post-fever onset), interim (>10 and <90 days), or chronic (≥90 days) cases. We observed a high prevalence of arthralgia (80-95%) across all ages over the study period. Overall, the odds of acute arthralgia increased in an age-dependent manner, with the lowest odds of arthralgia in the 0-4 y/o group (odds ratio [OR]: 0.27, 95% confidence interval [CI]: 0.14-0.51) and the highest odds of arthralgia in the 16+ y/o participants (OR: 4.91, 95% CI: 1.42-30.95) relative to 10-15 y/o participants. Females had higher odds of acute arthralgia than males (OR: 1.63, 95% CI: 1.01-2.65) across all ages. We found that 23-36% of pediatric and 53% of adult participants reported an instance of post-acute arthralgia. Children exhibited the highest prevalence of post-acute polyarthralgia in their legs, followed by the hands and torso - a pattern not seen among adult participants. Further, we observed pediatric chikungunya presenting in two distinct phases: the acute phase and the subsequent interim/chronic phases. Thus, differences in the presentation of arthralgia were observed across age, sex, and disease phase in this longitudinal chikungunya cohort. Our results elucidate the long-term burden of chikungunya-associated arthralgia among pediatric and adult populations.","journal":"PLoS neglected tropical diseases","year":2024,"id":430589,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6734,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236663,"name":"Fausto Andres Bustos Carrillo","orcid":"0000-0002-7263-5625","position":1,"is_corresponding":false},{"id":972152,"name":"José Víctor Zambrana","orcid":"0000-0003-0107-6173","position":2,"is_corresponding":false},{"id":236659,"name":"Brenda Lopez Mercado","orcid":"0000-0002-9584-2571","position":3,"is_corresponding":false},{"id":236658,"name":"Sonia Arguello","orcid":"0009-0005-0915-5273","position":4,"is_corresponding":false},{"id":1172250,"name":"Oscarlette Ampié","orcid":null,"position":5,"is_corresponding":false},{"id":236660,"name":"Damaris Collado","orcid":"0000-0002-0878-3260","position":6,"is_corresponding":false},{"id":236668,"name":"Nery Sánchez","orcid":"0000-0002-0070-3895","position":7,"is_corresponding":false},{"id":236667,"name":"Sergio Ojeda","orcid":"0000-0003-2512-2306","position":8,"is_corresponding":false},{"id":236672,"name":"Guillermina Kuan","orcid":"0000-0002-5251-173X","position":9,"is_corresponding":false},{"id":227052,"name":"Aubree Gordon","orcid":"0000-0002-9352-7877","position":10,"is_corresponding":false},{"id":236673,"name":"Ángel Balmaseda","orcid":"0000-0003-1174-4235","position":11,"is_corresponding":false},{"id":236674,"name":"Eva Harris","orcid":"0000-0002-7238-4037","position":12,"is_corresponding":false},{"id":590522,"name":"Colin M. Warnes","orcid":"0000-0003-3088-8429","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:59:20.861374Z","pmid":"38416797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}