{"doi":"10.1371/journal.pntd.0010561","title":"Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population","abstract":"BACKGROUND: The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in a South Indian adult population. METHODS: To this end, we performed community-based screening of 2351 individuals (aged 18-65) in Kanchipuram District of Tamil Nadu between 2013 and 2020. Serological testing for S. stercoralis was performed using the NIE ELISA. RESULTS: Our data shows a seroprevalence of 33% (768/2351) for S. stercoralis infection which had a higher prevalence among males 36% (386/1069) than among females 29.8% (382/1282). Adults aged ≥55 (aOR = 1.65, 95% CI: 1.25-2.18) showed higher adjusted odds of association compared with other age groups. Eosinophil levels (39%) (aOR = 1.43, 95% CI: 1.19-1.74) and hemoglobin levels (24%) (aOR = 1.25, 95% CI: 1.11-1.53) were significantly associated with S. stercoralis infection. In contrast, low BMI (aOR = 1.15, 95% CI: 0.82-1.61) or the presence of diabetes mellitus (OR = 1.18, 95% CI: 0.83-1.69) was not associated with S. stercoralis seropositivity. CONCLUSIONS: Our study provides evidence for a very high baseline prevalence of S. stercoralis infection in South Indian communities and this information could provide realistic and concrete planning of control measures.","journal":"PLoS neglected tropical diseases","year":2022,"id":255536,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7168,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":351532,"name":"Anuradha Rajamanickam","orcid":"0000-0002-8143-5502","position":1,"is_corresponding":false},{"id":18854,"name":"Suganthi Balasubramanian","orcid":"0000-0003-2243-5948","position":2,"is_corresponding":false},{"id":904388,"name":"Satishwaran Muthusamy","orcid":null,"position":3,"is_corresponding":false},{"id":326393,"name":"Chandra Kumar Dolla","orcid":"0000-0003-2978-3267","position":4,"is_corresponding":false},{"id":352411,"name":"Pradeep A. Menon","orcid":null,"position":5,"is_corresponding":false},{"id":904389,"name":"Ponnuraja Chinnayan","orcid":null,"position":6,"is_corresponding":false},{"id":903733,"name":"Christopher Whalen","orcid":"0000-0002-1379-7392","position":7,"is_corresponding":false},{"id":904390,"name":"Paschaline Gumne","orcid":null,"position":8,"is_corresponding":false},{"id":904391,"name":"Inderdeep Kaur","orcid":null,"position":9,"is_corresponding":false},{"id":904392,"name":"Varma Nadimpalli","orcid":null,"position":10,"is_corresponding":false},{"id":904393,"name":"Akshay Deverakonda","orcid":null,"position":11,"is_corresponding":false},{"id":903734,"name":"Zhenhao Chen","orcid":"0000-0003-1803-8894","position":12,"is_corresponding":false},{"id":904394,"name":"John David Otto","orcid":null,"position":13,"is_corresponding":false},{"id":904395,"name":"Tesfalidet Habitegiyorgis","orcid":null,"position":14,"is_corresponding":false},{"id":904396,"name":"Harish Kandaswamy","orcid":null,"position":15,"is_corresponding":false},{"id":287794,"name":"Thomas B. Nutman","orcid":"0000-0001-6887-4941","position":16,"is_corresponding":false},{"id":299467,"name":"Subash Babu","orcid":"0000-0001-9783-8042","position":17,"is_corresponding":false},{"id":397446,"name":"Saravanan Munisankar","orcid":"0000-0001-8394-0038","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T00:25:17.224217Z","pmid":"35857754","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}