{"doi":"10.1371/journal.pntd.0009459","title":"Correlation between reported dengue illness history and seropositivity in rural Thailand","abstract":"In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person's history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30.6 years (range 0-90 years). Individual and family member dengue illness histories were obtained by questionnaire. Seropositivity was defined based on hemagglutination inhibition (HAI) assays. Overall seropositivity for DENV was 86.5% among those aged 9-45 years, which increased with age. 18.5% of participants reported a history of dengue illness prior to enrollment; 30.1% reported a previous DENV infection in the family, and 40.1% reported DENV infection in either themselves or a family member. Relative to seropositivity by HAI in the vaccine candidate group, the sensitivity and specificity of individual prior dengue illness history were 18.5% and 81.6%, respectively; sensitivity and specificity of reported dengue illness in a family member were 29.8% and 68.0%, and of either the individual or a family member were 40.1% and 60.5%. Notably, 13.4% of individuals reporting prior dengue illness were seronegative. Given the high occurrence of asymptomatic and mild DENV infection, self-reported dengue illness history is poorly sensitive for prior exposure and may misclassify individuals as 'exposed' when they were not. This analysis highlights that a simple, highly sensitive, and highly specific test for determining serostatus prior to Dengvaxia vaccination is urgently needed.","journal":"PLoS neglected tropical diseases","year":2021,"id":206736,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9659,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364843,"name":"Kathryn B. Anderson","orcid":"0000-0002-5725-2351","position":1,"is_corresponding":false},{"id":290878,"name":"Gregory D. Gromowski","orcid":"0000-0003-4576-4277","position":2,"is_corresponding":false},{"id":290899,"name":"Richard G. Jarman","orcid":"0000-0002-5765-0173","position":3,"is_corresponding":false},{"id":364846,"name":"Sopon Iamsirithaworn","orcid":"0000-0002-6109-5002","position":4,"is_corresponding":false},{"id":566536,"name":"Butsaya Thaisomboonsuk","orcid":null,"position":5,"is_corresponding":false},{"id":656864,"name":"Taweewun Hunsawong","orcid":"0000-0002-0330-6334","position":6,"is_corresponding":false},{"id":364845,"name":"Anon Srikiatkhachorn","orcid":"0000-0002-2423-8545","position":7,"is_corresponding":false},{"id":364851,"name":"Alan L. Rothman","orcid":"0000-0002-4064-6848","position":8,"is_corresponding":false},{"id":733131,"name":"Anthony R. Jones","orcid":null,"position":9,"is_corresponding":false},{"id":364850,"name":"Stefan Fernandez","orcid":"0000-0001-8471-6265","position":10,"is_corresponding":false},{"id":65334,"name":"Stephen J. Thomas","orcid":"0000-0002-8368-7682","position":11,"is_corresponding":false},{"id":471562,"name":"Timothy P. Endy","orcid":"0000-0001-9152-0199","position":12,"is_corresponding":false},{"id":364844,"name":"Darunee Buddhari","orcid":"0000-0001-7984-1707","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:51:41.571653Z","pmid":"34129599","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}