{"doi":"10.1371/journal.pntd.0009183","title":"Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells","abstract":"Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study, we used Asian-American lineage ZIKV strain PRVABC59 to infect primary human NS/PCs originally derived from fetal brains. We found that ZIKV overactivated key molecules in the innate immune pathways to impair neurogenesis in a cell stage-dependent manner. Inhibiting the overactivated innate immune responses ameliorated ZIKV-induced neurogenesis reduction. This study thus suggests that orchestrating the host innate immune responses in NS/PCs after ZIKV infection could be promising therapeutic approach to attenuate ZIKV-associated neuropathology.","journal":"PLoS neglected tropical diseases","year":2021,"id":197769,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9661,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":396907,"name":"Junling Gao","orcid":"0000-0002-9727-1338","position":1,"is_corresponding":false},{"id":254584,"name":"Chao Shan","orcid":"0000-0002-3953-3782","position":2,"is_corresponding":false},{"id":468718,"name":"Tiffany Dunn","orcid":null,"position":3,"is_corresponding":false},{"id":105317,"name":"Xuping Xie","orcid":"0000-0003-0918-016X","position":4,"is_corresponding":false},{"id":105303,"name":"Hongjie Xia","orcid":"0000-0002-2520-7038","position":5,"is_corresponding":false},{"id":105308,"name":"Jing Zou","orcid":"0000-0002-8098-7284","position":6,"is_corresponding":false},{"id":772281,"name":"Beatriz H. Thames","orcid":null,"position":7,"is_corresponding":false},{"id":772282,"name":"Amulya Sajja","orcid":null,"position":8,"is_corresponding":false},{"id":467952,"name":"Yongjia Yu","orcid":"0000-0001-6007-8596","position":9,"is_corresponding":false},{"id":105315,"name":"Alexander N. Freiberg","orcid":"0000-0001-8413-8960","position":10,"is_corresponding":false},{"id":286063,"name":"Nikos Vasilakis","orcid":"0000-0002-0708-3289","position":11,"is_corresponding":false},{"id":38215,"name":"Pei‐Yong Shi","orcid":"0000-0001-5553-1616","position":12,"is_corresponding":false},{"id":105319,"name":"Scott C. Weaver","orcid":"0000-0001-8016-8556","position":13,"is_corresponding":false},{"id":396911,"name":"Ping Wu","orcid":"0000-0002-7020-6237","position":14,"is_corresponding":false},{"id":468,"name":"Pei Xu","orcid":"0000-0002-9480-8021","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-18T23:50:23.532351Z","pmid":"33657175","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}