{"doi":"10.1371/journal.pntd.0008414","title":"CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens","abstract":"Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 receptor has been described as important to the interaction between antigen-presenting cells and effector cells. We hypothesized that CXCR3 is fundamental to T. cruzi-specific CD8+ T cell activation, migration and effector function. Anti-CXCR3 neutralizing antibody administration to acutely T. cruzi-infected mice decreased the number of specific CD8+ T cells in the spleen, and those cells had impaired in activation and cytokine production but unaltered proliferative response. In addition, anti-CXCR3-treated mice showed decreased frequency of CD8+ T cells in the heart and numbers of plasmacytoid dendritic cells in spleen and lymph node. As CD8+ T cells interacted with plasmacytoid dendritic cells during infection by T. cruzi, we suggest that anti-CXCR3 treatment lowers the quantity of plasmacytoid dendritic cells, which may contribute to impair the prime of CD8+ T cells. Understanding which molecules and mechanisms guide CD8+ T cell activation and migration might be a key to vaccine development against Chagas disease as those cells play an important role in T. cruzi infection control.","journal":"PLoS neglected tropical diseases","year":2020,"id":69817,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":369557,"name":"Leonardo de Moro Cariste","orcid":"0000-0001-7551-9307","position":1,"is_corresponding":false},{"id":369558,"name":"Isaú H. Noronha","orcid":"0000-0002-3676-9749","position":2,"is_corresponding":false},{"id":363604,"name":"Danielle Fernandes Durso","orcid":"0000-0002-8113-3838","position":3,"is_corresponding":false},{"id":353740,"name":"Joseli Lannes‐Vieira","orcid":"0000-0002-1495-3027","position":4,"is_corresponding":false},{"id":369559,"name":"Karina Ramalho Bortoluci","orcid":"0000-0001-6780-5397","position":5,"is_corresponding":false},{"id":369560,"name":"Daniel Araki Ribeiro","orcid":"0000-0001-5057-4983","position":6,"is_corresponding":false},{"id":225476,"name":"Douglas T. Golenbock","orcid":"0000-0002-2447-2358","position":7,"is_corresponding":false},{"id":305966,"name":"Ricardo T. Gazzinelli","orcid":"0000-0003-2427-7699","position":8,"is_corresponding":false},{"id":369561,"name":"José Ronnie Vasconcelos","orcid":"0000-0003-1126-7563","position":9,"is_corresponding":false},{"id":369556,"name":"Camila Pontes Ferreira","orcid":"0000-0002-3835-2197","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T21:42:48.813846Z","pmid":"32574175","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}