{"doi":"10.1371/journal.pgph.0005425","title":"Characterization of 843 children with Zika-related microcephaly in the first three years of life: An individual participant data meta-analysis of 12 cohorts in the Zika Brazilian Cohorts consortium","abstract":"One of the main gaps in characterizing the congenital Zika syndrome (CZS) up to now is the small number of participants in individual studies. Pooling the data together overcomes the sample size-related limitations of individual studies and provides an opportunity for investigating heterogeneity between studies and, as appropriate, to better characterize the CZS. This study aims to describe adverse anthropometric, clinical, and neuroimaging outcomes in Brazilian children with Zika-related microcephaly.Individual participant data meta-analysis of 12 cohorts of the Zika Brazilian Cohorts Consortium (ZBC-Consortium), using primary data from children with Zika-related microcephaly, born between January/2015 and July/2018. We included 843 children with microcephaly at birth, at first evaluation, or over follow-up. Of 601 children with microcephaly at birth, 217 (36.1%) had moderate and 384 (63.9%) had severe microcephaly. Postnatal microcephaly occurred in 172 (20.4%) children. There was heterogeneity across studies. Severe microcephaly ranged from 11-87.5%; prematurity from 10-20% in most sites; low birth weight from 10-43.8%. Deficit of social attention, hyperreflexia, and persistence of primitive reflexes were reported in at least 50% of the children in the larger cohorts. Epilepsy ranged from 30-80% of the children and dysphagia, from 22.2-67.7%. Calcifications and ventriculomegaly were the most consistent and frequent abnormality (around 80%). Cortical atrophy or other development disorders were reported in around 50% of the children. The frequency of fundal, optical nerve and hearing abnormalities ranged from 0-67.1%, 0-36.5% and 0-50%, respectively. This large sample size allowed us to describe the spectrum of severity and of manifestations of Congenital Zika Syndrome.","journal":"PLOS Global Public Health","year":2025,"id":549775,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":22.178386323199504,"corpus_rank":9377,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":6.25,"fair_percentile":25.068786303882604,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":872902,"name":"Ricardo Arraes de Alencar Ximenes","orcid":"0000-0002-9951-8840","position":1,"is_corresponding":false},{"id":1445014,"name":"U R Montarroyos","orcid":null,"position":2,"is_corresponding":false},{"id":873443,"name":"Marília Rosa Abtibol‐Bernardino","orcid":null,"position":3,"is_corresponding":false},{"id":305990,"name":"Elizabeth B. Brickley","orcid":"0000-0003-0280-2288","position":4,"is_corresponding":false},{"id":271996,"name":"Celina Maria Turchi Martelli","orcid":"0000-0002-2491-0688","position":5,"is_corresponding":false},{"id":496244,"name":"Laura C. Rodrigues","orcid":"0000-0001-9008-660X","position":6,"is_corresponding":false},{"id":1445015,"name":"Thalia Velho Barreto de Araújo","orcid":null,"position":7,"is_corresponding":false},{"id":872911,"name":"Liana O. Ventura","orcid":"0000-0001-6529-6883","position":8,"is_corresponding":false},{"id":1445016,"name":"Mariana C. Leal","orcid":null,"position":9,"is_corresponding":false},{"id":1444504,"name":"Darci Neves dos Santos","orcid":"0000-0003-1500-8294","position":10,"is_corresponding":false},{"id":1444505,"name":"Letícia Marques dos Santos","orcid":"0000-0001-5963-2166","position":11,"is_corresponding":false},{"id":1445017,"name":"Lucas Monteiro Santos","orcid":null,"position":12,"is_corresponding":false},{"id":1444506,"name":"Mariana Rabelo Gomes","orcid":"0000-0001-9875-7308","position":13,"is_corresponding":false},{"id":480636,"name":"Isadora Cristina de Siqueira","orcid":"0000-0002-2520-4099","position":14,"is_corresponding":false},{"id":1123853,"name":"Leticia Serra","orcid":null,"position":15,"is_corresponding":false},{"id":1445018,"name":"Débora Patrícia Medeiros Santos Rios","orcid":null,"position":16,"is_corresponding":false},{"id":1445019,"name":"Alessandra Carvalho","orcid":null,"position":17,"is_corresponding":false},{"id":1445020,"name":"Antônio Moura Silva","orcid":null,"position":18,"is_corresponding":false},{"id":1445021,"name":"Patrícia Silva Sousa","orcid":null,"position":19,"is_corresponding":false},{"id":1445022,"name":"Marizélia Costa Ribeiro","orcid":null,"position":20,"is_corresponding":false},{"id":1445023,"name":"Marcos Garcia Campos","orcid":null,"position":21,"is_corresponding":false},{"id":1445024,"name":"S. D. Passos","orcid":null,"position":22,"is_corresponding":false},{"id":1445025,"name":"Ana Paula Paschoalicchio Bertozzi","orcid":null,"position":23,"is_corresponding":false},{"id":1444507,"name":"Rosa Estela Gazeta","orcid":"0000-0003-2527-9880","position":24,"is_corresponding":false},{"id":1444508,"name":"Daniel Thomé Catalan","orcid":"0000-0003-1898-8339","position":25,"is_corresponding":false},{"id":1444509,"name":"Ricardo Queiroz Gurgel","orcid":"0000-0001-9651-3713","position":26,"is_corresponding":false},{"id":1444510,"name":"Aline de Siqueira Alves Lopes","orcid":"0000-0002-3254-3793","position":27,"is_corresponding":false},{"id":1444511,"name":"Andréa Monteiro Correia Medeiros","orcid":"0000-0002-4930-7623","position":28,"is_corresponding":false},{"id":1445026,"name":"Patricia Cristina Brasil","orcid":null,"position":29,"is_corresponding":false},{"id":305511,"name":"Karin Nielsen‐Saines","orcid":"0000-0002-1742-5211","position":30,"is_corresponding":false},{"id":1445027,"name":"Zilton C. Vasconcelos","orcid":null,"position":31,"is_corresponding":false},{"id":305515,"name":"Andréa Zin","orcid":"0000-0001-7677-0034","position":32,"is_corresponding":false},{"id":1445028,"name":"Marisa Márcia Mussi-Pinhata","orcid":null,"position":33,"is_corresponding":false},{"id":1445029,"name":"Silvia Fabiana Biason de Moura Negrini","orcid":null,"position":34,"is_corresponding":false},{"id":1445030,"name":"Bento Vidal de Moura Negrini","orcid":null,"position":35,"is_corresponding":false},{"id":1445031,"name":"C. Feito Caldas","orcid":null,"position":36,"is_corresponding":false},{"id":1444512,"name":"Daniela Vivacqua","orcid":"0000-0002-1124-5922","position":37,"is_corresponding":false},{"id":1444513,"name":"Bernadete Perez Coêlho","orcid":"0000-0003-4956-183X","position":38,"is_corresponding":false},{"id":873445,"name":"Lucíola de Fátima Albuquerque de Almeida Peixoto","orcid":null,"position":39,"is_corresponding":false},{"id":452993,"name":"Camila Bôtto-Menezes","orcid":"0000-0001-6867-4931","position":40,"is_corresponding":false},{"id":873464,"name":"Silvana Gomes Benzecry","orcid":null,"position":41,"is_corresponding":false},{"id":872912,"name":"Consuelo Silva de Oliveira","orcid":"0000-0002-4105-5839","position":42,"is_corresponding":false},{"id":1444514,"name":"Joelma Karin Sagica Fernandes Paschoal","orcid":"0000-0001-6720-9720","position":43,"is_corresponding":false},{"id":873448,"name":"E Serra","orcid":null,"position":44,"is_corresponding":false},{"id":1445032,"name":"Luna Thais Sousa Gomes","orcid":null,"position":45,"is_corresponding":false},{"id":1445033,"name":"Maria Elisabeth Moreira","orcid":null,"position":46,"is_corresponding":false},{"id":872927,"name":"Cristina Barroso Hofer","orcid":"0000-0001-8633-0913","position":47,"is_corresponding":false},{"id":872903,"name":"Demócrito de Barros Miranda-Filho","orcid":"0000-0003-2537-1476","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T02:54:12.321988Z","pmid":"41460891","pmcid":"PMC12747325","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":11.1111,"fair_a":18.75,"fair_i":0.0,"fair_r":29.1667,"fair_zscore":-1.1162,"fair_rationale":{"fair_score":6.25,"has_llm":true,"taxonomy_version":"fair_taxonomy_v5","dimensions":{"F":{"name":"Findable","score":11.11,"criteria":[{"key":"f_dataset_pid","label":"Persistent identifier for the data","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"The paper provides no persistent identifier string (DOI, Handle, ARK, URN, or repository accession) for its own dataset.","anchors":["RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit","RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier'","FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'"],"scored":true,"signal":null},{"key":"f_repository_named","label":"Named repository","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No repository is named as the holder of the data; the only contact is an institutional email address, which is not a repository host. [majority verdict 'no' (3/5 passes agreed)]","anchors":["RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed (","NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived","NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten"],"scored":true,"signal":null},{"key":"f_data_availability_statement","label":"Data-availability statement","kind":"llm","weight":2.0,"fraction":0.5,"verdict":"partial","evidence":"Data generated and analyzed during this study is included in the article and its supplementary information files.","grounded":true,"rationale":"The statement points to the article and supplementary files as the location of the data, which is Colavizza category 2 (data contained within the article/supplementary materials).","anchors":["Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li","Springer Nature research data policy — Data Availability Statements: standard statement templat","RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes"],"scored":false,"signal":null},{"key":"f_discovery_metadata","label":"Description of the dataset as an object","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":"This study included individual participant data from children in the ZBC-Consortium with a definitive, highly probable, or moderately probable diagnosis of CZS and moderate or severe microcephaly.","grounded":false,"rationale":"The dataset's content is described in running prose, but there is no itemised inventory (section, table, or list) that enumerates files or variables. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (4/5 passes agreed)]","anchors":["RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential)","FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability'","FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'"],"scored":false,"signal":null},{"key":"f_dataset_cited","label":"Dataset formally cited","kind":"llm","weight":1.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No identifier for the paper's own dataset appears anywhere in the text, in the body or in the reference list.","anchors":["FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first-","RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes","FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'"],"scored":true,"signal":null}]},"A":{"name":"Accessible","score":18.75,"criteria":[{"key":"a_data_openly_accessible","label":"Access route free of preconditions","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":"de-identified data can be made available upon reasonable request from qualified investigators by contacting the Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco (UPE) at ppg.cienciasdasaude@upe.br.","grounded":true,"rationale":"The only route to the actual study data (the IPD) is a discretionary request to an institutional contact, which is not a followable process, so the data are not openly accessible. [majority verdict 'no' (4/5 passes agreed)]","anchors":["RDA-A1.1-01D — 'Data is accessible through a free access protocol'","FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data'","NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'"],"scored":true,"signal":null},{"key":"a_access_conditions_stated","label":"Access level labelled","kind":"llm","weight":1.0,"fraction":0.5,"verdict":"partial","evidence":"de-identified data can be made available upon reasonable request from qualified investigators by contacting the Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco (UPE) at ppg.cienciasdasaude@upe.br.","grounded":true,"rationale":"The paper describes the access action but does not apply a standard access-level label from the COAR vocabulary. [majority verdict 'partial' (3/5 passes agreed)]","anchors":["FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data'","RDA-A1-01M — metadata contains information to enable the user to get access to the data","COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl"],"scored":false,"signal":null},{"key":"a_controlled_access_for_sensitive","label":"Gatekeeper for sensitive data","kind":"llm","weight":0.5,"fraction":0.5,"verdict":"partial","evidence":"de-identified data can be made available upon reasonable request from qualified investigators by contacting the Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco (UPE) at ppg.cienciasdasaude@upe.br.","grounded":true,"rationale":"The gatekeeper is an institutional email address, not a named person, but also not a controlled-access repository or Data Access Committee; the route is a request to an institution, which is partial. [majority verdict 'partial' (4/5 passes agreed)]","anchors":["NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee","RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and ","NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse"],"scored":false,"signal":null},{"key":"a_timeline_retention","label":"Availability timing & retention","kind":"llm","weight":0.5,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No sentence in the paper addresses when the data become available or how long they persist. [majority verdict 'no' (4/5 passes agreed)]","anchors":["NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines","NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy'","RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'"],"scored":false,"signal":null}]},"I":{"name":"Interoperable","score":0.0,"criteria":[{"key":"i_open_nonproprietary_format","label":"Open file format","kind":"llm","weight":1.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No file format for the released data is named anywhere in the text.","anchors":["FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co","RDA-R1.3-02D — data is expressed in a machine-understandable community standard","RDA-I1-01D — data uses a knowledge representation expressed in a standardised format"],"scored":true,"signal":null},{"key":"i_community_standard_vocabulary","label":"Community standard / vocabulary","kind":"llm","weight":1.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"The paper does not name a FAIRsharing-registered data or metadata standard (e.g., MIAME, BIDS, an ontology).","anchors":["RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential)","RDA-R1.3-01D — 'Data complies with a community standard'","RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'"],"scored":false,"signal":null},{"key":"i_qualified_references","label":"Identifiers for the resources the data depend on","kind":"llm","weight":0.5,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No identifier for any external resource (e.g., another dataset accession, DOI, RRID, reference assembly) is given in the text. [majority verdict 'no' (3/5 passes agreed)]","anchors":["RDA-I3-01M — '(meta)data include references to other (meta)data'","RDA-I3-03M — 'metadata includes qualified references to other metadata'","FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'"],"scored":false,"signal":null}]},"R":{"name":"Reusable","score":29.17,"criteria":[{"key":"r_reuse_license","label":"Reuse licence","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No licence or terms document is named for the data; the Creative Commons Attribution license applies to the article, not the data. [majority verdict 'no' (4/5 passes agreed)]","anchors":["RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu","RDA-R1.1-02M — 'Metadata refers to a standard reuse licence'","RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'"],"scored":true,"signal":null},{"key":"r_provenance_methods","label":"Provenance of the data","kind":"llm","weight":1.0,"fraction":1.0,"verdict":"yes","evidence":"All analyses were performed using STATA, version 14 (College Station, TX, USA).","grounded":true,"rationale":"The paper names specific software (STATA version 14) used to produce the analysis data, meeting the named-tool class. [majority verdict 'yes' (3/5 passes agreed)]","anchors":["RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa","FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati","W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance"],"scored":false,"signal":null},{"key":"r_documentation_codebook","label":"Documentation / codebook","kind":"llm","weight":1.0,"fraction":0.0,"verdict":"no","evidence":"In the current study we evaluated: severity of microcephaly, proportionality, prematurity (gestational age of <37 weeks at delivery), low birth weight (birth weight of <2500g at delivery)…","grounded":false,"rationale":"Variable definitions are provided inside the article text (in the Methods section), but no separate documentation object (README, data dictionary) is said to accompany the data. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/5 passes agreed)]","anchors":["RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu","FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'","NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t"],"scored":false,"signal":null},{"key":"r_versioning","label":"Snapshot identified","kind":"llm","weight":0.5,"fraction":0.5,"verdict":"partial","evidence":"the latest evaluation was on October 17, 2019.","grounded":true,"rationale":"The paper provides a date (the latest evaluation date) that pins the snapshot of the data, but no version token. [majority verdict 'partial' (3/5 passes agreed)]","anchors":["DataCite Metadata Schema 4.6 — the 'Version' property","RDA-R1.2-01M — provenance information (which version was used is provenance)","NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'"],"scored":true,"signal":null},{"key":"x_code_availability","label":"Analysis code available","kind":"llm","weight":1.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"No code location or availability statement is given for the study's own analysis code.","anchors":["NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code'","FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear","FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)"],"scored":true,"signal":null},{"key":"x_funding_attribution","label":"Funder and award number","kind":"llm","weight":0.5,"fraction":1.0,"verdict":"yes","evidence":"Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (grant number 404861/2018-0 RAAX)","grounded":true,"rationale":"The paper lists specific grant numbers attached to named funders, satisfying the award-number class. [majority verdict 'yes' (4/5 passes agreed)]","anchors":["DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award","Crossref Funder Registry — canonical funder identifiers for funding metadata","RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco"],"scored":true,"signal":null}]}},"actions":[{"key":"f_dataset_pid","dimension":"F","label":"Persistent identifier for the data","action":"Mint or cite a persistent identifier for the dataset — a repository DOI or an accession from a registered repository — and print it in the paper. A bare URL is not persistent: it is the single most common cause of a dead data link five years after publication. For neuroimaging data, deposit in OpenNeuro or NeuroVault.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"The paper provides no persistent identifier string (DOI, Handle, ARK, URN, or repository accession) for its own dataset.","gain":16.67,"priority":"essential","scored":true},{"key":"f_repository_named","dimension":"F","label":"Named repository","action":"Deposit the data in a repository registered in re3data/FAIRsharing (a domain repository such as GEO, SRA, dbGaP, PRIDE, or a generalist such as Zenodo, Dryad, Dataverse) and name it explicitly in the paper. A lab website is not an archive: it has no retention commitment and no accession. For neuroimaging data, deposit in OpenNeuro or NeuroVault.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No repository is named as the holder of the data; the only contact is an institutional email address, which is not a repository host. [majority verdict 'no' (3/5 passes agreed)]","gain":16.67,"priority":"essential","scored":true},{"key":"a_data_openly_accessible","dimension":"A","label":"Access route free of preconditions","action":"Remove the precondition or justify it. Release the data at publication with no embargo, no registration wall, and no approval step — NIH's zero-embargo public- access rule (NOT-OD-25-101) has already made 'available at publication' the federal baseline for the article; the data should not lag behind it. For neuroimaging data, deposit in OpenNeuro or NeuroVault.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":"de-identified data can be made available upon reasonable request from qualified investigators by contacting the Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco (UPE) at ppg.cienciasdasaude@upe.br.","why":"The only route to the actual study data (the IPD) is a discretionary request to an institutional contact, which is not a followable process, so the data are not openly accessible. [majority verdict 'no' (4/5 passes agreed)]","gain":16.67,"priority":"essential","scored":true},{"key":"r_reuse_license","dimension":"R","label":"Reuse licence","action":"Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 'Free to use' is not a licence: it grants nothing a reuser's institution can rely on.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No licence or terms document is named for the data; the Creative Commons Attribution license applies to the article, not the data. [majority verdict 'no' (4/5 passes agreed)]","gain":16.67,"priority":"essential","scored":true},{"key":"f_dataset_cited","dimension":"F","label":"Dataset formally cited","action":"Cite the dataset in the reference list like a publication — creator, year, title, repository, DOI/accession — and cite it in-text where it is used. Only a reference- list entry is machine-readable to Crossref/DataCite, and only a citation lets the data earn credit. Cite the neuroimaging repository accession (e.g. from OpenNeuro or NeuroVault) in the reference list.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No identifier for the paper's own dataset appears anywhere in the text, in the body or in the reference list.","gain":8.33,"priority":"important","scored":true},{"key":"i_open_nonproprietary_format","dimension":"I","label":"Open file format","action":"Release the data in an open, community-standard format (CSV/TSV, JSON, HDF5, NetCDF, FASTQ, VCF, NIfTI…) instead of — or alongside — any proprietary or instrument-native format, and name the format in the paper. A dataset that needs a €2,000 licence to open is not reusable. Prefer open neuroimaging formats such as NIfTI or BIDS.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No file format for the released data is named anywhere in the text.","gain":8.33,"priority":"important","scored":true},{"key":"x_code_availability","dimension":"R","label":"Analysis code available","action":"Publish the analysis code in a public forge, archive a tagged release with a DOI (Zenodo/Software Heritage), and cite that DOI in the paper. NIH DMS Element 2 asks for the tools and code, not only the data — and 'available on request' is not a locator. Archive the analysis code in a versioned repository (GitHub + a Zenodo release DOI).","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No code location or availability statement is given for the study's own analysis code.","gain":8.33,"priority":"important","scored":true},{"key":"r_versioning","dimension":"R","label":"Snapshot identified","action":"Version the deposit and cite the exact version analysed (a version-specific DOI, or an accession with its version suffix). A reader reproducing your work against 'the current release' is reproducing it against a different dataset.","anchors":["yes","partial","no"],"verdict":"partial","current":0.5,"evidence":"the latest evaluation was on October 17, 2019.","why":"The paper provides a date (the latest evaluation date) that pins the snapshot of the data, but no version token. [majority verdict 'partial' (3/5 passes agreed)]","gain":2.08,"priority":"useful","scored":true},{"key":"f_data_availability_statement","dimension":"F","label":"Data-availability statement","action":"Replace the statement with the repository template: name the repository and give the accession or DOI (Colavizza category 3). This is the only DAS class associated with a measured citation advantage; 'available on reasonable request' and 'within the article' are not.","anchors":["yes","partial","no"],"verdict":"partial","current":0.5,"evidence":"Data generated and analyzed during this study is included in the article and its supplementary information files.","why":"The statement points to the article and supplementary files as the location of the data, which is Colavizza category 2 (data contained within the article/supplementary materials).","gain":0.0,"priority":"essential","scored":false},{"key":"f_discovery_metadata","dimension":"F","label":"Description of the dataset as an object","action":"Add a 'Data Records' section: itemise every file in the deposit and every variable or sample it holds, with counts and units. Describe the dataset as an object in its own right, not as a by-product of the findings — this is what makes it discoverable to someone who is not looking for your paper.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":"This study included individual participant data from children in the ZBC-Consortium with a definitive, highly probable, or moderately probable diagnosis of CZS and moderate or severe microcephaly.","why":"The dataset's content is described in running prose, but there is no itemised inventory (section, table, or list) that enumerates files or variables. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (4/5 passes agreed)]","gain":0.0,"priority":"essential","scored":false},{"key":"a_access_conditions_stated","dimension":"A","label":"Access level labelled","action":"State the access level in words, using the standard vocabulary: 'These data are open access' / 'These data are controlled access'. A reader — and a harvester — should not have to infer the access level from the presence of a download link.","anchors":["yes","partial","no"],"verdict":"partial","current":0.5,"evidence":"de-identified data can be made available upon reasonable request from qualified investigators by contacting the Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco (UPE) at ppg.cienciasdasaude@upe.br.","why":"The paper describes the access action but does not apply a standard access-level label from the COAR vocabulary. [majority verdict 'partial' (3/5 passes agreed)]","gain":0.0,"priority":"important","scored":false},{"key":"i_community_standard_vocabulary","dimension":"I","label":"Community standard / vocabulary","action":"Adopt and NAME your domain's data standard — the minimum-information checklist, metadata schema, or ontology your community uses (MIAME/MINSEQE, ISA-Tab, BIDS, an OBO ontology, HL7 FHIR/OMOP) — and say which one you followed. A reporting checklist standardises your paper; it does nothing for your data. In neuroimaging, describe the data with BIDS, NIfTI or DICOM.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"The paper does not name a FAIRsharing-registered data or metadata standard (e.g., MIAME, BIDS, an ontology).","gain":0.0,"priority":"important","scored":false},{"key":"r_documentation_codebook","dimension":"R","label":"Documentation / codebook","action":"Ship a README and a data dictionary IN the deposit — every file, every variable, its units, its allowed values, its missing-value codes. It is the cheapest single thing that makes a dataset usable by someone who was not in the lab, and a table buried in the article does not travel with the data.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":"In the current study we evaluated: severity of microcephaly, proportionality, prematurity (gestational age of <37 weeks at delivery), low birth weight (birth weight of <2500g at delivery)…","why":"Variable definitions are provided inside the article text (in the Methods section), but no separate documentation object (README, data dictionary) is said to accompany the data. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/5 passes agreed)]","gain":0.0,"priority":"important","scored":false},{"key":"a_controlled_access_for_sensitive","dimension":"A","label":"Gatekeeper for sensitive data","action":"Route sensitive data through an institutional gatekeeper — deposit in a controlled- access repository (dbGaP, EGA) with a Data Access Committee and a published DUA — rather than through the corresponding author's inbox. An author-gated dataset dies with the author's email address, and 'on reasonable request' has been shown repeatedly not to yield data.","anchors":["yes","partial","no"],"verdict":"partial","current":0.5,"evidence":"de-identified data can be made available upon reasonable request from qualified investigators by contacting the Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco (UPE) at ppg.cienciasdasaude@upe.br.","why":"The gatekeeper is an institutional email address, not a named person, but also not a controlled-access repository or Data Access Committee; the route is a request to an institution, which is partial. [majority verdict 'partial' (4/5 passes agreed)]","gain":0.0,"priority":"useful","scored":false},{"key":"i_qualified_references","dimension":"I","label":"Identifiers for the resources the data depend on","action":"Cite by identifier every resource the data depend on — the source datasets' accessions, the reference build (GRCh38 / GCA_000001405.28), the cohort application number, the code DOI — and register those relations on the dataset record (IsDerivedFrom, IsSupplementTo). A name is not a link: it cannot be resolved, versioned, or followed by a machine.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No identifier for any external resource (e.g., another dataset accession, DOI, RRID, reference assembly) is given in the text. [majority verdict 'no' (3/5 passes agreed)]","gain":0.0,"priority":"useful","scored":false},{"key":"a_timeline_retention","dimension":"A","label":"Availability timing & retention","action":"State when the data become available AND how long they will be retained — cite the repository's preservation policy. NIH DMS Element 4 asks for both; most papers give neither.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No sentence in the paper addresses when the data become available or how long they persist. [majority verdict 'no' (4/5 passes agreed)]","gain":0.0,"priority":"useful","scored":false}],"suggestions":["Mint or cite a persistent identifier for the dataset — a repository DOI or an accession from a registered repository — and print it in the paper. A bare URL is not persistent: it is the single most common cause of a dead data link five years after publication. For neuroimaging data, deposit in OpenNeuro or NeuroVault.","Deposit the data in a repository registered in re3data/FAIRsharing (a domain repository such as GEO, SRA, dbGaP, PRIDE, or a generalist such as Zenodo, Dryad, Dataverse) and name it explicitly in the paper. A lab website is not an archive: it has no retention commitment and no accession. For neuroimaging data, deposit in OpenNeuro or NeuroVault.","Remove the precondition or justify it. Release the data at publication with no embargo, no registration wall, and no approval step — NIH's zero-embargo public- access rule (NOT-OD-25-101) has already made 'available at publication' the federal baseline for the article; the data should not lag behind it. For neuroimaging data, deposit in OpenNeuro or NeuroVault.","Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 'Free to use' is not a licence: it grants nothing a reuser's institution can rely on.","Cite the dataset in the reference list like a publication — creator, year, title, repository, DOI/accession — and cite it in-text where it is used. Only a reference- list entry is machine-readable to Crossref/DataCite, and only a citation lets the data earn credit. Cite the neuroimaging repository accession (e.g. from OpenNeuro or NeuroVault) in the reference list."],"model":"deepseek/deepseek-v4-flash","agent_version":"fair_agent_v8","fulltext_source":"epmc_xml"},"fair_model":"deepseek/deepseek-v4-flash","fair_agent_version":"fair_agent_v8","fair_fulltext_source":"epmc_xml","fair_has_llm":true,"fair_computed_at":"2026-07-20T13:46:18.247858Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}